合成路线1

1) The condensation of 1,3-dibromopropane (II) with diethyl phosphonate (III) gives diethyl 3-bromopropylphosphonate (IV), which by reaction with butyraldehyde oxime (V) by means of sodium ethoxide in ethanol is converted to diethyl 3-(butylideneamino)propylphosphonate-N-oxide (VI). Finally, this compound is hydrolyzed with HCl in refluxing acetic acid to obtain compound (I). 2) The condensation of (IV) with N-(p-methoxybenzyloxy)-p-toluenesulfonamide (VII) by means of sodium ethoxide in ethanol gives diethyl 3-[N-methoxybenzyloxy)-N-tosylamino]propyl phosphonate (VIII), which is hydrolyzed with HCl in acetic acid to obtain compound (I). 3) The condensation of (IV) with methyl N-(benzyloxy)carbamate (IX) by means of sodium ethoxide in ethanol yields diethyl 3-(N-benzyloxy-N-methoxycarbonylamino)propylphosphonate (X), which is hydrolyzed with HCl in acetic acid to obtain compound (I). 4) The condensation of (IV) with hydroxylamine by means of NaOH in MeOH-H2O gives diethyl 3-(N-hydroxylamino)propylphosphonate (XI), which is hydrolyzed with HCl in acetic acid to obtain compound (I).