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【结 构 式】

【分子编号】39038

【品名】3-chloropyridine

【CA登记号】626-60-8

【 分 子 式 】C5H4ClN

【 分 子 量 】113.5462

【元素组成】C 52.89% H 3.55% Cl 31.22% N 12.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

1 Pieterse, M.J.; Den Hertog, H.J.; Rearrangements during aminations of halopyridines, presumably involving a pyridine intermediate. Recl Trav Chim Pays-Bas 1961, 80, 1376-86.
2 Suzuki, Y.; Reactions of 4-pyridine- and 4-quinolinesulfonic acids with amines. Yakugaku Zasshi 1961, 81, 1146-50.
3 Hayashi, E.; Yamanaka, H.; JP 6115616 .
4 Serradell, M.N.; Blancafort, P.; Castaner, J.; Paton, D.M.; 4-Aminopyridine. Drugs Fut 1980, 5, 5, 221.
5 Rauch, F.C.; Arzoumanidis, G.G.; DE 2258227 .
6 Rauch, F.C.; Arzoumanidis, G.G.; US 3812137 .
7 Koenig, C.; et al.; DE 1270563 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 39036 4-pyridinesulfonic acid C5H5NO3S 详情 详情
(II) 39037 4-nitropyridine C5H4N2O2 详情 详情
(III) 25028 isonicotinic acid 55-22-1 C6H5NO2 详情 详情
(IV) 32889 4-chloropyridine 7379-35-3 C5H4ClN 详情 详情
(V) 39038 3-chloropyridine 626-60-8 C5H4ClN 详情 详情
(VI) 39039 4-iodopyridine C5H4IN 详情 详情
(VII) 29108 3-iodopyridine C5H4IN 详情 详情
Extended Information