2-[[2-[bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]acetic acid -Drug Synthesis Database

【结构式】

【分子编号】39018

【品名】2-[[2-[bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]acetic acid

【CA登记号】

【分子式】C₁₀H₁₆N₂O₈

【分子量】292.24572

【元素组成】C 41.1% H 5.52% N 9.59% O 43.8%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Ethylenediaminetetraacetic acid (EDTA) (I) on heating with formamide (A), afforded IGRF-154 (II). The latter compound was suspended in dimethylformamide (C), heated with morpholine (B) in ethanol and then refluxed with formalin. The final product crystallized on cooling.

参考文献中间体

合成目标

【1】 Ren, Y.F.; et al.; An investigation of a new antineoplastic agent bimolane (AT-1727). Kexue Tongbao 1980, 23, 4, 189-190.
【2】 Ji Ru-Yun; Bimolane. Drugs Fut 1981, 6, 11, 667.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	10388	Morpholine	110-91-8	C₄H₉NO	详情	详情
(A)	16598	Formamide	75-12-7	CH₃NO	详情	详情
(I)	39018	2-[[2-[bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]acetic acid		C₁₀H₁₆N₂O₈	详情	详情
(II)	28033	4-[2-(3,5-dioxo-1-piperazinyl)ethyl]-2,6-piperazinedione		C₁₀H₁₄N₄O₄	详情	详情
(C)	33491	Dimethylformamide	68-12-2	C₃H₇NO	详情	详情

Extended Information