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【结 构 式】 
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【药物名称】Bimolane, AT-1727 【化学名称】4,4'-(1,2-Ethanediyl)bis[1-(4-morpholinyl)piperazine-2,6-dione] 【CA登记号】74550-97-3 【 分 子 式 】C20H32N6O6 【 分 子 量 】452.51464 |
【开发单位】Henan Medical University (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
Ethylenediaminetetraacetic acid (EDTA) (I) on heating with formamide (A), afforded IGRF-154 (II). The latter compound was suspended in dimethylformamide (C), heated with morpholine (B) in ethanol and then refluxed with formalin. The final product crystallized on cooling.
| 【1】 Ren, Y.F.; et al.; An investigation of a new antineoplastic agent bimolane (AT-1727). Kexue Tongbao 1980, 23, 4, 189-190. |
| 【2】 Ji Ru-Yun; Bimolane. Drugs Fut 1981, 6, 11, 667. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
| (A) | 16598 | Formamide | 75-12-7 | CH3NO | 详情 | 详情 |
| (I) | 39018 | 2-[[2-[bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]acetic acid | C10H16N2O8 | 详情 | 详情 | |
| (II) | 28033 | 4-[2-(3,5-dioxo-1-piperazinyl)ethyl]-2,6-piperazinedione | C10H14N4O4 | 详情 | 详情 | |
| (C) | 33491 | Dimethylformamide | 68-12-2 | C3H7NO | 详情 | 详情 |
Extended Information