4-amino-N-(tert-butyl)benzamide -Drug Synthesis Database

【结构式】

【分子编号】38445

【品名】4-amino-N-(tert-butyl)benzamide

【CA登记号】

【分子式】C₁₁H₁₆N₂O

【分子量】192.26092

【元素组成】C 68.72% H 8.39% N 14.57% O 8.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

4-Nitrobenzoyl chloride (I) was condensed with tert-butyl amine to give amide (II). The nitro group of (II) was then reduced to aniline (III) by transfer hydrogenation with hydrazine and Pd/C. Finally, acylation of (III) with acetyl chloride provided the title acetamide.

参考文献中间体

合成目标

【1】 Sorbera, L.A.; Castañer, J.; Leeson, P.A.; CPI-1189. Drugs Fut 2001, 26, 7, 647.
【2】 Flitter, W.D.; Irwin, I.; Garland, W.A. (Centaur Pharmaceuticals, Inc.); Benzamide therapeutics for the treatment of inflammatory bowel disease. WO 9959569 .
【3】 Garland, W.A.; Wilcox, A.L.; Paylor, R.E.; Flitter, W.D. (Centaur Pharmaceuticals, Inc.); Benzamides for neurodegenerative disorder treatment. US 5955506; WO 9631462 .
【4】 Garland, W. (Centaur Pharmaceuticals, Inc.); Benzamide treatment of dementia, associated with AIDS virus (HIV-1) infection. WO 9738684 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18941	p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride	122-04-3	C₇H₄ClNO₃	详情	详情
(II)	38444	N-(tert-butyl)-4-nitrobenzamide		C₁₁H₁₄N₂O₃	详情	详情
(III)	38445	4-amino-N-(tert-butyl)benzamide		C₁₁H₁₆N₂O	详情	详情

Extended Information