1-(methoxymethylene)cyclododecane; cyclododecylidenemethyl methyl ether -Drug Synthesis Database

【结构式】

【分子编号】42362

【品名】1-(methoxymethylene)cyclododecane; cyclododecylidenemethyl methyl ether

【CA登记号】

【分子式】C₁₄H₂₆O

【分子量】210.35984

【元素组成】C 79.94% H 12.46% O 7.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Bishydroperoxide (III) was prepared by treatment of cyclododecanone (I) with hydrogen peroxide in formic acid or, alternatively, by ozonolysis of vinyl ether (II) in the presence of hydrogen peroxide at -70 C. Alkylation of bishydroperoxide (III) with 1,3-diiodopropane (IV) and CsOH in DMF furnished the title spirotetraoxane.

参考文献中间体

合成目标

【1】 Tsuchiya, K.; et al.; Synthesis, crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes. Tetrahedron Lett 1999, 40, 21, 4077.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42361	cyclododecanone	830-13-7	C₁₂H₂₂O	详情	详情
(II)	42362	1-(methoxymethylene)cyclododecane; cyclododecylidenemethyl methyl ether		C₁₄H₂₆O	详情	详情
(III)	42363	1-hydroperoxycyclododecyl hydroperoxide		C₁₂H₂₄O₄	详情	详情
(IV)	42364	1,3-diiodopropane	627-31-6	C₃H₆I₂	详情	详情

Extended Information