N-89, -Drug Synthesis Database

【结构式】

【药物名称】N-89

【化学名称】1,2,6,7-Tetraoxaspiro[7.11]nonadecane

【CA登记号】229323-98-2

【分子式】C₁₅H₂₈O₄

【分子量】272.38801

【开发单位】Okayama University (Originator), Osaka University (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases

合成路线1

Bishydroperoxide (III) was prepared by treatment of cyclododecanone (I) with hydrogen peroxide in formic acid or, alternatively, by ozonolysis of vinyl ether (II) in the presence of hydrogen peroxide at -70 C. Alkylation of bishydroperoxide (III) with 1,3-diiodopropane (IV) and CsOH in DMF furnished the title spirotetraoxane.

参考文献中间体

【1】 Tsuchiya, K.; et al.; Synthesis, crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes. Tetrahedron Lett 1999, 40, 21, 4077.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42361	cyclododecanone	830-13-7	C₁₂H₂₂O	详情	详情
(II)	42362	1-(methoxymethylene)cyclododecane; cyclododecylidenemethyl methyl ether		C₁₄H₂₆O	详情	详情
(III)	42363	1-hydroperoxycyclododecyl hydroperoxide		C₁₂H₂₄O₄	详情	详情
(IV)	42364	1,3-diiodopropane	627-31-6	C₃H₆I₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)