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【结 构 式】 
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【分子编号】41973 【品名】1-(1-benzyl-4-piperidinyl)-1H-pyrrole-3-carbaldehyde 【CA登记号】 |
【 分 子 式 】C17H20N2O 【 分 子 量 】268.35868 【元素组成】C 76.09% H 7.51% N 10.44% O 5.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of 4-amino-1-benzylpiperidine (I) with 2,5-dimethoxytetrahydrofuran-3-carbaldehyde (II) under modified Paal-Knorr conditions produced the pyrrole derivative (III). Construction of the target oxazole ring was then achieved by cyclocondensation reaction of aldehyde (III) with tosylmethyl isocyanide in the presence of NaOMe.
| 【1】 Hubner, H.; Gmeiner, P.; Haubmann, C.; Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett 1999, 9, 21, 3143. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34808 | 1-Benzyl-4-piperidinylamine; 1-Benzyl-4-piperidinamine; 4-Amino-1-benzylpiperidine | 50541-93-0 | C12H18N2 | 详情 | 详情 |
| (II) | 26664 | 2,5-dimethoxytetrahydro-3-furancarbaldehyde | C7H12O4 | 详情 | 详情 | |
| (III) | 41973 | 1-(1-benzyl-4-piperidinyl)-1H-pyrrole-3-carbaldehyde | C17H20N2O | 详情 | 详情 |
Extended Information