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【结 构 式】 
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【药物名称】 【化学名称】1-Benzyl-4-[3-(5-oxazolyl)-1H-pyrrol-1-yl]piperidine 【CA登记号】 【 分 子 式 】C19H21N3O 【 分 子 量 】307.39872 |
【开发单位】Friedrich-Alexander-Universität (Originator) 【药理作用】Antipsychotic Drugs, PSYCHOPHARMACOLOGIC DRUGS, Dopamine D4 Antagonists |
合成路线1
The condensation of 4-amino-1-benzylpiperidine (I) with 2,5-dimethoxytetrahydrofuran-3-carbaldehyde (II) under modified Paal-Knorr conditions produced the pyrrole derivative (III). Construction of the target oxazole ring was then achieved by cyclocondensation reaction of aldehyde (III) with tosylmethyl isocyanide in the presence of NaOMe.
| 【1】 Hubner, H.; Gmeiner, P.; Haubmann, C.; Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett 1999, 9, 21, 3143. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34808 | 1-Benzyl-4-piperidinylamine; 1-Benzyl-4-piperidinamine; 4-Amino-1-benzylpiperidine | 50541-93-0 | C12H18N2 | 详情 | 详情 |
| (II) | 26664 | 2,5-dimethoxytetrahydro-3-furancarbaldehyde | C7H12O4 | 详情 | 详情 | |
| (III) | 41973 | 1-(1-benzyl-4-piperidinyl)-1H-pyrrole-3-carbaldehyde | C17H20N2O | 详情 | 详情 |
Extended Information