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【结 构 式】

【分子编号】41582

【品名】(2R)-2-amino-3-[[4-(dimethylamino)benzyl]sulfanyl]propionic acid

【CA登记号】

【 分 子 式 】C12H18N2O2S

【 分 子 量 】254.3532

【元素组成】C 56.67% H 7.13% N 11.01% O 12.58% S 12.61%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(V)

The treatment of 4-(dimethylamino)benzyl alcohol (I) with concentrated HBr at 120 C in a sealed tube provided benzyl bromide (II). This was then condensed with N-Boc-L-cysteine (III) in the presence of N,N-diisopropyl ethylamine to furnish the benzyl thioether (IV). Subsequent cleavage of the Boc group of (IV) employing HCl in dioxan yielded the intermediate aminoacid (V).

1 Miyake, Y.; Horiuchi, M.; Mita, S.; Tsuji, F.; Involvement of leukotriene B4 in murine dermatitis models. Biochem Pharmacol 1998, 55, 297.
2 Kawashima, Y.; Horiuchi, M. (Santen Pharmaceutical Co., Ltd.); Novel amino acid derivs. having N,N-dialkylaminophenyl group. EP 0870762; JP 1996301840; WO 9627585 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 41579 [4-(dimethylamino)phenyl]methanol 1703-46-4 C9H13NO 详情 详情
(II) 41580 4-(bromomethyl)-N,N-dimethylaniline; N-[4-(bromomethyl)phenyl]-N,N-dimethylamine C9H12BrN 详情 详情
(III) 20812 (2R)-2-[(tert-butoxycarbonyl)amino]-3-sulfanylpropionic acid 20887-95-0 C8H15NO4S 详情 详情
(IV) 41581 (2R)-2-[(tert-butoxycarbonyl)amino]-3-[[4-(dimethylamino)benzyl]sulfanyl]propionic acid C17H26N2O4S 详情 详情
(V) 41582 (2R)-2-amino-3-[[4-(dimethylamino)benzyl]sulfanyl]propionic acid C12H18N2O2S 详情 详情

合成路线2

该中间体在本合成路线中的序号:(V)

(S)-3-Benzoylthio-2-methylpropionic acid (VI) was activated as the acid chloride (VII) by treatment with SOCl2 or optionally converted to the active ester (VIII) upon condensation with p-nitrophenol in the presence of DCC. Coupling of aminoacid (V) with either acid chloride (VII) under Schotten-Baumann conditions or with p-nitrophenyl ester (VIII) in the presence of Et3N gave rise to the corresponding amide (IX). The benzoyl thioester of (IX) was finally cleaved employing aqueous ammonia to afford the title thiol.

1 Miyake, Y.; Horiuchi, M.; Mita, S.; Tsuji, F.; Involvement of leukotriene B4 in murine dermatitis models. Biochem Pharmacol 1998, 55, 297.
2 Kawashima, Y.; Horiuchi, M. (Santen Pharmaceutical Co., Ltd.); Novel amino acid derivs. having N,N-dialkylaminophenyl group. EP 0870762; JP 1996301840; WO 9627585 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 41582 (2R)-2-amino-3-[[4-(dimethylamino)benzyl]sulfanyl]propionic acid C12H18N2O2S 详情 详情
(VI) 35379 (2S)-3-(benzoylsulfanyl)-2-methylpropionic acid C11H12O3S 详情 详情
(VII) 41584 S-[(2R)-3-chloro-2-methyl-3-oxopropyl] benzenecarbothioate C11H11ClO2S 详情 详情
(VIII) 35380 4-nitrophenyl (2S)-3-(benzoylsulfanyl)-2-methylpropanoate C17H15NO5S 详情 详情
(IX) 41583 (2R)-2-[[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]amino]-3-[[4-(dimethylamino)benzyl]sulfanyl]propionic acid C23H28N2O4S2 详情 详情
Extended Information