[(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl dihydrogen phosphate -Drug Synthesis Database

【结构式】

【分子编号】38262

【品名】[(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl dihydrogen phosphate

【CA登记号】

【分子式】C₁₀H₁₄N₅O₇P

【分子量】347.224422

【元素组成】C 34.59% H 4.06% N 20.17% O 32.25% P 8.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

The phosphorylation of AZT (VI) with POCl3 trimethyl phosphate gives the 5'-O-phosphate (VII), which is then condensed with the previously described thioester (III) by means of Tps-Cl in pyridine.

参考文献中间体

合成目标

【1】 Lannuzel, M.; et al.; Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches. Nucleosides Nucleotides 1999, 18, 4-5, 1001.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	38259	S-(2-hydroxyethyl) 2,2-dimethylpropanethioate		C₇H₁₄O₂S	详情	详情
(VI)	25317	1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione	101703-35-9	C₁₀H₁₃N₅O₄	详情	详情
(VII)	38262	[(2S,3S,5R)-3-azido-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl dihydrogen phosphate		C₁₀H₁₄N₅O₇P	详情	详情

Extended Information