|
【结 构 式】 
|
【分子编号】38236 【品名】4-[(2R)-2-[(1S,3S,5R)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione 【CA登记号】66-81-9 |
【 分 子 式 】C15H23NO4 【 分 子 量 】281.35196 【元素组成】C 64.04% H 8.24% N 4.98% O 22.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)By condensation of cycloheximide (I) with ethyl 2-bromoacetate (II) by means of K2CO3 and 18-crown-6 in acetone.
| 【1】 Grabley, S.; Wyrwa, R.; Schummann, D.; Marsch, S.; Christner, C.; Küllertz, G.; Fischer, G.; Thiericke, R.; Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem 1999, 42, 18, 3615. |
| 【2】 Thiericke, R.; Fischer, G.; Küllertz, G.; Christner, C.; Grabley, S.; Wyrwa, R. (Hans Knöll Institute for Natural Product Research; Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ); Cyclohexamide derivs. which influence the regeneration of neural tissue. WO 0026188 . |
Extended Information