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【结 构 式】 
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【药物名称】 【化学名称】2-[4-[2(R)-[3(S),5(R)-Dimethyl-2-oxo-1(S)-cyclohexyl]-2-hydroxyethyl]-2,6-dioxopiperidin-1-yl]acetic acid ethyl ester 【CA登记号】246257-13-6 【 分 子 式 】C19H29NO6 【 分 子 量 】367.44608 |
【开发单位】Friedrich-Schiller-Universität Jena (Originator), Hans Knöll Institute Natural Prod. Res. (Originator), Max-Planck-Gesellschaft (Originator) 【药理作用】Antiparkinsonian Drugs, Cerebrovascular Diseases, Treatment of, Cognition Disorders, Treatment of, Extrapyramidal Disorders, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Neurotrophic Agents, Rotamase (FKBP12) Inhibitors |
合成路线1
By condensation of cycloheximide (I) with ethyl 2-bromoacetate (II) by means of K2CO3 and 18-crown-6 in acetone.
| 【1】 Grabley, S.; Wyrwa, R.; Schummann, D.; Marsch, S.; Christner, C.; Küllertz, G.; Fischer, G.; Thiericke, R.; Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem 1999, 42, 18, 3615. |
| 【2】 Thiericke, R.; Fischer, G.; Küllertz, G.; Christner, C.; Grabley, S.; Wyrwa, R. (Hans Knöll Institute for Natural Product Research; Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ); Cyclohexamide derivs. which influence the regeneration of neural tissue. WO 0026188 . |
Extended Information