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【结 构 式】 
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【分子编号】38235 【品名】1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C9H12N2O6 【 分 子 量 】244.20416 【元素组成】C 44.27% H 4.95% N 11.47% O 39.31% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of 6-chloropurine-2-amine (I) with methanol and NaH gives 6-O-methylguanine (II), which is mixed with uracil arabinoside (III), purine nucleoside phosphorylase and uridine phosphorylase and submitted to incubation in a potassium phosphate solution at 37 C. After 26 days of incubation, the target compound is isolated.
| 【1】 Krenitsky, T.A.; Koszalka, G.W.; Jones, L.A.; Averett, D.R.; Moorman, A.R. (Glaxo Wellcome plc); Antiviral cpds.. AU 8816718; EP 0294114; JP 1988310831; US 5424295; US 5539098 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11644 | 6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine | 10310-21-1 | C5H4ClN5 | 详情 | 详情 |
| (II) | 38234 | 6-methoxy-9H-purin-2-amine; 6-methoxy-9H-purin-2-ylamine | 20535-83-5 | C6H7N5O | 详情 | 详情 |
| (III) | 38235 | 1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C9H12N2O6 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)
| 【1】 Krmitsky TA. 1988. Antiviral compounds. EP 0294114[本专利为GlaxoSmithKline (GB)所有] |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11996 | 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione; Uridine | 58-96-8 | C9H12N2O6 | 详情 | 详情 |
| (II) | 66535 | (2R,3S,3aS,9aR)-3-hydroxy-2-(hydroxymethyl)-3,3a-dihydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6(9aH)-one | C9H10N2O5 | 详情 | 详情 | |
| (III) | 38235 | 1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C9H12N2O6 | 详情 | 详情 |
Extended Information