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【结 构 式】

【分子编号】38149

【品名】5-amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione

【CA登记号】

【 分 子 式 】C10H10N2O5S

【 分 子 量 】270.26588

【元素组成】C 44.44% H 3.73% N 10.37% O 29.6% S 11.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Condensation of 4-nitrophthalic anhydride (I) with O-benzyl hydroxylamine in refluxing toluene produced phthalimide (II). Catalytic transfer hydrogenation employing cyclohexene in the presence of Pd/C yielded 4-amino-N-hydroxyphthalimide (III), which was condensed with ethanesulfonyl chloride to give sulfonate (IV). Finally, acylation with acid chloride (V) furnished the title compound.

1 Kerrigan, J.E.; et al.; 6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase. Bioorg Med Chem Lett 2000, 10, 1, 27.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
14640 O-benzylhydroxylamine; 1-[(aminooxy)methyl]benzene 622-33-3 C7H9NO 详情 详情
(I) 31028 5-nitro-2-benzofuran-1,3-dione 5466-84-2 C8H3NO5 详情 详情
(II) 38147 2-(benzyloxy)-5-nitro-1H-isoindole-1,3(2H)-dione C15H10N2O5 详情 详情
(III) 38148 5-amino-2-hydroxy-1H-isoindole-1,3(2H)-dione C8H6N2O3 详情 详情
(IV) 38149 5-amino-2-[(ethylsulfonyl)oxy]-1H-isoindole-1,3(2H)-dione C10H10N2O5S 详情 详情
(V) 20650 methyl 5-chloro-5-oxopentanoate; methyl-4-chloroformylbutyrate 1501-26-4 C6H9ClO3 详情 详情
Extended Information