2-imino-8-methoxy-2H-chromene-3-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】38139

【品名】2-imino-8-methoxy-2H-chromene-3-carboxamide

【CA登记号】

【分子式】C₁₁H₁₀N₂O₃

【分子量】218.21208

【元素组成】C 60.55% H 4.62% N 12.84% O 22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of 3-methoxysalicylaldehyde (I) with cyanoacetamide (II) in the presence of piperidine gave rise to the carbamoyl iminochromene (III). Subsequent condensation of (III) with 3,4,5-trimethoxybenzaldehyde furnished the title compound.

参考文献中间体

合成目标

【1】 Perry, P.J.; McGown, A.T.; Pavlidis, V.H.; Hadfield, J.A.; Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines. Anti-Cancer Drugs 1999, 10, 6, 591.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12620	o-Vanillin; 2-Hydroxy-3-methoxybenzaldehyde	148-53-8	C₈H₈O₃	详情	详情
(II)	12122	Cyanoacetamide; 2-Cyanoacetamide	107-91-5	C₃H₄N₂O	详情	详情
(III)	38139	2-imino-8-methoxy-2H-chromene-3-carboxamide		C₁₁H₁₀N₂O₃	详情	详情
(IV)	11136	3,4,5-Trimethoxybenzaldehyde	86-81-7	C₁₀H₁₂O₄	详情	详情

Extended Information