|
【结 构 式】 
|
【药物名称】 【化学名称】9-Methoxy-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-[1]benzopyrano[2,3-d]pyrimidin-4-one 【CA登记号】 【 分 子 式 】C21H20N2O6 【 分 子 量 】396.40335 |
【开发单位】Cancer Research UK (Originator), De Montfort University (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
Condensation of 3-methoxysalicylaldehyde (I) with cyanoacetamide (II) in the presence of piperidine gave rise to the carbamoyl iminochromene (III). Subsequent condensation of (III) with 3,4,5-trimethoxybenzaldehyde furnished the title compound.
| 【1】 Perry, P.J.; McGown, A.T.; Pavlidis, V.H.; Hadfield, J.A.; Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines. Anti-Cancer Drugs 1999, 10, 6, 591. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12620 | o-Vanillin; 2-Hydroxy-3-methoxybenzaldehyde | 148-53-8 | C8H8O3 | 详情 | 详情 |
| (II) | 12122 | Cyanoacetamide; 2-Cyanoacetamide | 107-91-5 | C3H4N2O | 详情 | 详情 |
| (III) | 38139 | 2-imino-8-methoxy-2H-chromene-3-carboxamide | C11H10N2O3 | 详情 | 详情 | |
| (IV) | 11136 | 3,4,5-Trimethoxybenzaldehyde | 86-81-7 | C10H12O4 | 详情 | 详情 |
Extended Information