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【结 构 式】

【分子编号】37925

【品名】(2S)-N-[3-([4-[[(acetoxy)imino](amino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide

【CA登记号】

【 分 子 式 】C36H38Cl2N6O7S

【 分 子 量 】769.70536

【元素组成】C 56.18% H 4.98% Cl 9.21% N 10.92% O 14.55% S 4.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

In an alternative procedure, amine (II) was condensed with 4-cyanobenzoic acid (III) to give amide (IV). Subsequent addition of hydroxylamine to the cyano group of (IV) afforded N-hydroxy amidine (V), which was acetylated with Ac2O to produce (VI). This compound was finally reduced to the target amidine by hydrogenation over Lindlar catalyst.

1 Dodey, P.; Bondoux, M.; Ou, K.; Barth, M.; Houziaux, P. (Fournier Industrie et Santé); Novel N-benzenesulphonyl-L-proline derivs., method for preparing and therapeutic use. EP 0944618; US 6063791; WO 9824783 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 37922 (2S)-N-(3-aminopropyl)-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide C26H30Cl2N4O4S 详情 详情
(III) 36897 4-cyanobenzoic acid;4-Carboxybenzonitrile;p-Carboxybenzonitrile 619-65-8 C8H5NO2 详情 详情
(IV) 37923 (2S)-N-[3-[(4-cyanobenzoyl)amino]propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide C34H33Cl2N5O5S 详情 详情
(V) 37924 (2S)-N-[3-([4-[amino(hydroxyimino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide C34H36Cl2N6O6S 详情 详情
(VI) 37925 (2S)-N-[3-([4-[[(acetoxy)imino](amino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide C36H38Cl2N6O7S 详情 详情
Extended Information