【结 构 式】 |
【分子编号】37924 【品名】(2S)-N-[3-([4-[amino(hydroxyimino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide 【CA登记号】 |
【 分 子 式 】C34H36Cl2N6O6S 【 分 子 量 】727.66808 【元素组成】C 56.12% H 4.99% Cl 9.74% N 11.55% O 13.19% S 4.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)In an alternative procedure, amine (II) was condensed with 4-cyanobenzoic acid (III) to give amide (IV). Subsequent addition of hydroxylamine to the cyano group of (IV) afforded N-hydroxy amidine (V), which was acetylated with Ac2O to produce (VI). This compound was finally reduced to the target amidine by hydrogenation over Lindlar catalyst.
【1】 Dodey, P.; Bondoux, M.; Ou, K.; Barth, M.; Houziaux, P. (Fournier Industrie et Santé); Novel N-benzenesulphonyl-L-proline derivs., method for preparing and therapeutic use. EP 0944618; US 6063791; WO 9824783 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(II) | 37922 | (2S)-N-(3-aminopropyl)-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide | C26H30Cl2N4O4S | 详情 | 详情 | |
(III) | 36897 | 4-cyanobenzoic acid;4-Carboxybenzonitrile;p-Carboxybenzonitrile | 619-65-8 | C8H5NO2 | 详情 | 详情 |
(IV) | 37923 | (2S)-N-[3-[(4-cyanobenzoyl)amino]propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide | C34H33Cl2N5O5S | 详情 | 详情 | |
(V) | 37924 | (2S)-N-[3-([4-[amino(hydroxyimino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide | C34H36Cl2N6O6S | 详情 | 详情 | |
(VI) | 37925 | (2S)-N-[3-([4-[[(acetoxy)imino](amino)methyl]benzoyl]amino)propyl]-1-[(2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl)sulfonyl]-2-pyrrolidinecarboxamide | C36H38Cl2N6O7S | 详情 | 详情 |
Extended Information