• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】37446

【品名】ethyl (E)-6-[4-[(chlorocarbonyl)oxy]-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methyl-4-hexenoate

【CA登记号】

【 分 子 式 】C20H23ClO7

【 分 子 量 】410.85112

【元素组成】C 58.47% H 5.64% Cl 8.63% O 27.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The reaction of ethyl mycophenolate (I) with phosgene in benzene gives ethyl 5-(4'-chloroformyloxy-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl)-3-methyl-3-penten-1-carboxylate (II), which is then condensed with p-aminobenzoic acid (III) in THF.

1 Mori, T.; et al.; DE 2237549 .
2 Serradell, M.N.; Castaner, J.; Blancafort, P.; Hillier, K.; CAM. Drugs Fut 1981, 6, 5, 272.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 37445 ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-4-hexenoate C19H24O6 详情 详情
(II) 37446 ethyl (E)-6-[4-[(chlorocarbonyl)oxy]-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methyl-4-hexenoate C20H23ClO7 详情 详情
(III) 20004 p-aminobenzoic acid; 4-aminobenzoic acid 150-13-0 C7H7NO2 详情 详情
Extended Information