CAM, -Drug Synthesis Database

【结构式】

【药物名称】CAM

【化学名称】Ethyl O-[N-(p-carboxyphenyl)carbamoyl]mycophenolate
　　　　　　Ethyl 5-[4'-[N-(p-carboxyphenyl)carbamoyloxy]-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl]-3-methyl-3-penten-1-carboxylate
　　　　　　4-[[[[5-(6-Ethoxy-3-methyl-6-oxo-2-hexenyl)-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl]oxy]carbonyl]amino]benzoic acid

【CA登记号】40449-96-5 ((E)-isomer)

【分子式】C₂₇H₂₉NO₉

【分子量】511.53348

【开发单位】Ajinomoto (Originator), Chugai (Originator)

【药理作用】IMMUNOMODULATING AGENTS, Immunosuppressants, Oncolytic Drugs

合成路线1

The reaction of ethyl mycophenolate (I) with phosgene in benzene gives ethyl 5-(4'-chloroformyloxy-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl)-3-methyl-3-penten-1-carboxylate (II), which is then condensed with p-aminobenzoic acid (III) in THF.

参考文献中间体

【1】 Mori, T.; et al.; DE 2237549 .
【2】 Serradell, M.N.; Castaner, J.; Blancafort, P.; Hillier, K.; CAM. Drugs Fut 1981, 6, 5, 272.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37445	ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-4-hexenoate		C₁₉H₂₄O₆	详情	详情
(II)	37446	ethyl (E)-6-[4-[(chlorocarbonyl)oxy]-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methyl-4-hexenoate		C₂₀H₂₃ClO₇	详情	详情
(III)	20004	p-aminobenzoic acid; 4-aminobenzoic acid	150-13-0	C₇H₇NO₂	详情	详情

Extended Information

FDA Approved Drug Products(96)