1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione -Drug Synthesis Database

【结构式】

【分子编号】37193

【品名】1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【分子式】C₁₀H₁₄N₂O₆

【分子量】258.23104

【元素组成】C 46.51% H 5.46% N 10.85% O 37.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The reaction of 1-(2-deoxy-beta-D-ribofuranosyl)uracil (V) with CH2O and KOH gives 1-(2-deoxy-beta-D-ribofuranosyl)-5-hydroxymethyluracil (VI), which is treated with methanolic-HCl. Chromatography on silica gel yields the target compound.

参考文献中间体

合成目标

【1】 Gupta, V.S.; Bubbar, G.L.; Synthesis of 5-substituted ether derivatives of 5-hydroxymethyl deoxyuridine and their 'alpha-anomers'. Can J Chem 1970, 48, 20, 3147.
【2】 Gupta, V.S.; Methoxymethyl-2'-deoxyuridine. Drugs Fut 1981, 6, 1, 32.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	11875	1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione; 2'-Deoxyuridine	951-78-0	C₉H₁₂N₂O₅	详情	详情
(VI)	37193	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione		C₁₀H₁₄N₂O₆	详情	详情

Extended Information