N-(3-methoxyphenethyl)-N-phenethyl-N-propylamine; N-(3-methoxyphenethyl)-N-phenethyl-1-propanamine -Drug Synthesis Database

【结构式】

【分子编号】37187

【品名】N-(3-methoxyphenethyl)-N-phenethyl-N-propylamine; N-(3-methoxyphenethyl)-N-phenethyl-1-propanamine

【CA登记号】

【分子式】C₂₀H₂₇NO

【分子量】297.44052

【元素组成】C 80.76% H 9.15% N 4.71% O 5.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The reaction of 3-methoxyphenylethylamine (I) with phenylethyl bromide (II) in refluxing triethylamine gives 3-methoxy-N-(phenylethyl)phenylethylamine (III), which is alkylated with 1-iodopropane by means of K2CO3 in refluxing acetone yielding 3-methoxy-N-propyl-N-(phenylethyl)phenylethylamine (IV). Finally, this compound is demethylated by treatment with refluxing aqueous 48% HBr and formation of the HCl salt with hydrochloric acid.

参考文献中间体

合成目标

【1】 Nedelec, L.; et al.; Synthesis of study of the dopaminergic activity of di(phenylethyl)amine derivatives. Eur J Med Chem - Chim Ther 1978, 13, 6, 553-556.
【2】 Serradell, M.N.; Castañer, J.; Blancafort, P.; Owen, R.T.; RU-24213. Drugs Fut 1981, 6, 4, 237.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37185	2-(3-methoxyphenyl)-1-ethanamine; 3-methoxyphenethylamine	2039-67-0	C₉H₁₃NO	详情	详情
(II)	20730	1-(2-bromoethyl)benzene；1-Bromo-2-phenylethane;(2-Bromoethyl)benzene;Phenethyl bromide	103-63-9	C₈H₉Br	详情	详情
(III)	37186	N-(3-methoxyphenethyl)-N-phenethylamine; 2-(3-methoxyphenyl)-N-phenethyl-1-ethanamine		C₁₇H₂₁NO	详情	详情
(IV)	28758	1-iodopropane	107-08-4	C₃H₇I	详情	详情
(V)	37187	N-(3-methoxyphenethyl)-N-phenethyl-N-propylamine; N-(3-methoxyphenethyl)-N-phenethyl-1-propanamine		C₂₀H₂₇NO	详情	详情

Extended Information