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【结 构 式】

【分子编号】37126

【品名】 

【CA登记号】

【 分 子 式 】C10H18NO

【 分 子 量 】168.25906

【元素组成】C 71.38% H 10.78% N 8.32% O 9.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:

By condensation of ethyl 8-propyl-7-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylate (I) with 4-(2,3-epoxypropoxy)-3-propyl-2-hydroxyacetophenone (II) by means of benzyltrimethylammonium hydroxide in refluxing DMF, followed by hydrolysis with NaHCO3 in refluxing ethanol - water. The starting compounds (I) and (II) are prepared as follows: 1) The condensation of 3-propyl-2,4-dihydroxyacetophenone (III) with diethyl oxalate (IV) by means of sodium ethoxide in refluxing ethanol gives (I). 2) The condensation of acetophenone (III) with 1-chloro-2,3-epoxypropane (V) by means of KOH in refluxing ethanol - water gives (II).

1 Pratt, A.D.; Bantick, J..; Lee, T.B.; Chamberlain, T.R.; Hardern, D.N.; Appleton, R.A.; Antagonits of slow reacting substance od anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids. J Med Chem 1979, 20, 3, 371.
2 Augstein, J.; Lee, T.B.; Carter, D. (AstraZeneca plc); Chromone derivs.. FR 2147287 .
3 Augstein, J.; Carter, D.; Lee, T.B. (AstraZeneca plc); Chrome cpds. having SRS-A properties. US 3882148 .
4 Blancafort, P.; Castaner, J.; Sneddon, J.M.; Serradell, M.N.; FPL-55,712. Drugs Fut 1982, 7, 7, 472.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
37126   C10H18NO 详情 详情
(I) 37124 ethyl 7-hydroxy-4-oxo-8-propyl-4H-chromene-2-carboxylate C15H16O5 详情 详情
(II) 37125 1-[2-hydroxy-4-(2-oxiranylmethoxy)-3-propylphenyl]-1-ethanone C14H18O4 详情 详情
(III) 13137 2',4'-Dihydroxy-3'-propylacetophenone; 1-(2,4-Dihydroxy-3-propylphenyl)-1-ethanone 40786-69-4 C11H14O3 详情 详情
(IV) 17571 Diethyl oxalate; Ethyl 2-ethoxy-2-oxoacetate 95-92-1 C6H10O4 详情 详情
(V) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
Extended Information