【结 构 式】 |
【分子编号】37074 【品名】1-[2-hydroxy-6-(2-hydroxypropoxy)-3-propylphenyl]-1-ethanone 【CA登记号】 |
【 分 子 式 】C14H20O4 【 分 子 量 】252.3104 【元素组成】C 66.65% H 7.99% O 25.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)The hydrogenation of 2-hydroxy-3-allyl-6-(2-hydroxypropoxy)acetophenone (I) with H2 over Pd/C in ethanol gives 2-hydroxy-3-propyl-6-(2-hydroxypropoxy)acetophenone (II), which is then cyclized with diethyl oxalate (III) by means of sodium ethoxide in refluxing ethanol. The sodium salt is prepared by treatment of the acid with NaHCO3 in water.
【1】 Cairns, H.; Hazard, R.; King, J.; Lee, T.B.; DE 2530289 . |
【2】 Sneddon, J.M.; Serradell, M.N.; Castaner, J.; Blancafort, P.; FPL-52,694. Drugs Fut 1982, 7, 6, 388. |
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