1-[3-allyl-2-hydroxy-6-(2-hydroxypropoxy)phenyl]-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】37073

【品名】1-[3-allyl-2-hydroxy-6-(2-hydroxypropoxy)phenyl]-1-ethanone

【CA登记号】

【分子式】C₁₄H₁₈O₄

【分子量】250.29452

【元素组成】C 67.18% H 7.25% O 25.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The hydrogenation of 2-hydroxy-3-allyl-6-(2-hydroxypropoxy)acetophenone (I) with H2 over Pd/C in ethanol gives 2-hydroxy-3-propyl-6-(2-hydroxypropoxy)acetophenone (II), which is then cyclized with diethyl oxalate (III) by means of sodium ethoxide in refluxing ethanol. The sodium salt is prepared by treatment of the acid with NaHCO3 in water.

参考文献中间体

合成目标

【1】 Cairns, H.; Hazard, R.; King, J.; Lee, T.B.; DE 2530289 .
【2】 Sneddon, J.M.; Serradell, M.N.; Castaner, J.; Blancafort, P.; FPL-52,694. Drugs Fut 1982, 7, 6, 388.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37073	1-[3-allyl-2-hydroxy-6-(2-hydroxypropoxy)phenyl]-1-ethanone		C₁₄H₁₈O₄	详情	详情
(II)	37074	1-[2-hydroxy-6-(2-hydroxypropoxy)-3-propylphenyl]-1-ethanone		C₁₄H₂₀O₄	详情	详情
(III)	17571	Diethyl oxalate; Ethyl 2-ethoxy-2-oxoacetate	95-92-1	C₆H₁₀O₄	详情	详情

Extended Information