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【结 构 式】

【分子编号】37069

【品名】3-[4-(diethoxymethyl)benzyl]pyridine; ethoxy[4-(3-pyridinylmethyl)phenyl]methyl ethyl ether

【CA登记号】

【 分 子 式 】C17H21NO2

【 分 子 量 】271.35928

【元素组成】C 75.25% H 7.8% N 5.16% O 11.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of 3-chloromethylpyridine (I) with the Grignard reagent of 4-bromobenzaldehyde diethylacetal (II) in THF gives 4-(3-pyridylmethyl)benzaldehyde diethylacetal (III), which is hydrolyzed with aqueous 1N HCl to 4-(3-pyridylmethyl)benzaldehyde (IV). The Wittig condensation of (IV) with 1-(ethoxycarbonyl)ethylidenetriphenylphosphorane (V) in CHCl3 affords 3-[4-(3-pyridylmethyl)phenyl]-2-methylacryl ic acid ethyl ester (VI), which is finally hydrolyzed with aqueous NaOH.

1 Tanouchi, T.; et al.; Pyridine derivatives. DE 2951786; FR 2445319; FR 2510108; GB 2039903; US 4271170; US 4317828 .
2 Hillier, K.; Serradell, M.N.; Blancafort, P.; Castaner, J.; OKY-1581. Drugs Fut 1982, 7, 6, 399.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15793 3-(Chloromethyl)pyridine 3099-31-8 C6H6ClN 详情 详情
(II) 23171 bromo[4-(diethoxymethyl)phenyl]magnesium C11H15BrMgO2 详情 详情
(III) 37069 3-[4-(diethoxymethyl)benzyl]pyridine; ethoxy[4-(3-pyridinylmethyl)phenyl]methyl ethyl ether C17H21NO2 详情 详情
(IV) 37070 4-(3-pyridinylmethyl)benzaldehyde C13H11NO 详情 详情
(V) 37071 ethyl 2-(triphenylphosphoranylidene)propanoate 5717-37-3 C23H23O2P 详情 详情
(VI) 37072 ethyl (E)-2-methyl-3-[4-(3-pyridinylmethyl)phenyl]-2-propenoate C18H19NO2 详情 详情
Extended Information