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【结 构 式】

【分子编号】37059

【品名】2-bicyclo[2.2.1]hept-2-ylphenol

【CA登记号】

【 分 子 式 】C13H16O

【 分 子 量 】188.26944

【元素组成】C 82.94% H 8.57% O 8.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of sodium 2-(2-exo-norbornyl)phenoxide [from 2-bicyclo[2.2.1]hept-2-ylphenol (I) and sodium] with epichlorohydrin (II) gives (III), which is then treated with isopropylamine (IV) and finally with isopropanolic HCl.

1 FR 75/09997; FR 76/24360 .
2 Michaud, R.; Bornaprolol hydrochloride. Drugs Fut 1982, 7, 2, 91.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 37059 2-bicyclo[2.2.1]hept-2-ylphenol C13H16O 详情 详情
(II) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(III) 37060 2-[(2-bicyclo[2.2.1]hept-2-ylphenoxy)methyl]oxirane; 2-bicyclo[2.2.1]hept-2-ylphenyl 2-oxiranylmethyl ether C16H20O2 详情 详情
(IV) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
Extended Information