Bornaprolol hydrochloride, FM-24, -Drug Synthesis Database

【结构式】

【药物名称】Bornaprolol hydrochloride, FM-24

【化学名称】(±)-1-(2-exo-Byciclo[2.2.1]hept-2-ylphenoxy)-3-[(1-methylethylamino]-2-propanol hydrochloride
　　　　　　(±)-1-(Isopropylamino)-3-(o-2-exo-norbornylphenoxy)-2-propanol

【CA登记号】69319-47-7, 66451-06-7 (free base)

【分子式】C₁₉H₃₀ClNO₂

【分子量】339.90945

【开发单位】Pharmuka (Originator)

【药理作用】beta-Adrenoceptor Antagonists

合成路线1

The condensation of sodium 2-(2-exo-norbornyl)phenoxide [from 2-bicyclo[2.2.1]hept-2-ylphenol (I) and sodium] with epichlorohydrin (II) gives (III), which is then treated with isopropylamine (IV) and finally with isopropanolic HCl.

参考文献中间体

【1】 FR 75/09997; FR 76/24360 .
【2】 Michaud, R.; Bornaprolol hydrochloride. Drugs Fut 1982, 7, 2, 91.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37059	2-bicyclo[2.2.1]hept-2-ylphenol		C₁₃H₁₆O	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	37060	2-[(2-bicyclo[2.2.1]hept-2-ylphenoxy)methyl]oxirane; 2-bicyclo[2.2.1]hept-2-ylphenyl 2-oxiranylmethyl ether		C₁₆H₂₀O₂	详情	详情
(IV)	23933	2-Propanamine; Isopropylamine	75-31-0	C₃H₉N	详情	详情

Extended Information