1-(4-bromobenzyl)-1H-imidazole -Drug Synthesis Database

【结构式】

【分子编号】38402

【品名】1-(4-bromobenzyl)-1H-imidazole

【CA登记号】

【分子式】C₁₀H₉BrN₂

【分子量】237.09894

【元素组成】C 50.66% H 3.83% Br 33.7% N 11.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

This compound has been obtained by condensation of 1-(4-bromobenzyl)imidazole (I) with 4-fluorophenylboronic acid (II) by means of Pd(PPh3)4 and Na2CO3 in refluxing toluene/ethanol.

参考文献中间体

合成目标

【1】 Wachall, B.G.; et al.; Imidazole substituted biphenyls: A new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer. Bioorg Med Chem 1999, 7, 9, 1913.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	38402	1-(4-bromobenzyl)-1H-imidazole		C₁₀H₉BrN₂	详情	详情
(II)	38403	4-fluorophenylboronic acid	1765-93-1	C₆H₆BFO₂	详情	详情

Extended Information