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【结 构 式】 
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【药物名称】 【化学名称】1-(4'-Fluorobiphenyl-4-ylmethyl)-1H-imidazole 【CA登记号】 【 分 子 式 】C16H13FN2 【 分 子 量 】252.29381 |
【开发单位】Universität des Saarlandes (Originator) 【药理作用】Oncolytic Drugs, Prostate Cancer Therapy, 17alpha-Hydroxylase/C17-20 Lyase Inhibitors |
合成路线1
This compound has been obtained by condensation of 1-(4-bromobenzyl)imidazole (I) with 4-fluorophenylboronic acid (II) by means of Pd(PPh3)4 and Na2CO3 in refluxing toluene/ethanol.
| 【1】 Wachall, B.G.; et al.; Imidazole substituted biphenyls: A new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer. Bioorg Med Chem 1999, 7, 9, 1913. |
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