ethyl 2-[4-oxo-1,2,3-benzotriazin-3(4H)-yl]acetate -Drug Synthesis Database

【结构式】

【分子编号】36891

【品名】ethyl 2-[4-oxo-1,2,3-benzotriazin-3(4H)-yl]acetate

【CA登记号】

【分子式】C₁₁H₁₁N₃O₃

【分子量】233.22676

【元素组成】C 56.65% H 4.75% N 18.02% O 20.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of 1,2,3-benzotriazin-4(3H)-one (I) with ethyl bromoacetate (II) in refluxing butanone afforded the 3-(ethoxycarbonylmethyl) derivative (III). The ethyl ester group of (III) was then converted into the target amide by reaction with N,N-diethylethylenediamine (IV) in hot MeOH

参考文献中间体

合成目标

【1】 Caliendo, G.; De Nucci, G.; Meli, R.; Mattace Raso, G.; Fiorino, F.; Perissutti, E.; Zanesco, A.; Grieco, P.; Santagada, V.; Preparation and local anaesthetic activity of benzotriazinone and benzoyltriazole derivatives. Eur J Med Chem 1999, 34, 12, 1043.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36890	1,2,3-benzotriazin-4(3H)-one		C₇H₅N₃O	详情	详情
(II)	16640	Ethyl 2-bromoacetate; Ethyl bromoacetate	105-36-2	C₄H₇BrO₂	详情	详情
(III)	36891	ethyl 2-[4-oxo-1,2,3-benzotriazin-3(4H)-yl]acetate		C₁₁H₁₁N₃O₃	详情	详情
(IV)	12420	N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine	100-36-7	C₆H₁₆N₂	详情	详情

Extended Information