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【结 构 式】

【药物名称】

【化学名称】N-[2-(Diethylamino)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide

【CA登记号】

【 分 子 式 】C15H21N5O2

【 分 子 量 】303.36692

【开发单位】Università degli Studi di Napoli (Originator)

【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Anesthetic Drugs, Local Anesthetics

合成路线1

Condensation of 1,2,3-benzotriazin-4(3H)-one (I) with ethyl bromoacetate (II) in refluxing butanone afforded the 3-(ethoxycarbonylmethyl) derivative (III). The ethyl ester group of (III) was then converted into the target amide by reaction with N,N-diethylethylenediamine (IV) in hot MeOH

1 Caliendo, G.; De Nucci, G.; Meli, R.; Mattace Raso, G.; Fiorino, F.; Perissutti, E.; Zanesco, A.; Grieco, P.; Santagada, V.; Preparation and local anaesthetic activity of benzotriazinone and benzoyltriazole derivatives. Eur J Med Chem 1999, 34, 12, 1043.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 36890 1,2,3-benzotriazin-4(3H)-one C7H5N3O 详情 详情
(II) 16640 Ethyl 2-bromoacetate; Ethyl bromoacetate 105-36-2 C4H7BrO2 详情 详情
(III) 36891 ethyl 2-[4-oxo-1,2,3-benzotriazin-3(4H)-yl]acetate C11H11N3O3 详情 详情
(IV) 12420 N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine 100-36-7 C6H16N2 详情 详情
Extended Information