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【结 构 式】 
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【药物名称】 【化学名称】N-[2-(Diethylamino)ethyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide 【CA登记号】 【 分 子 式 】C15H21N5O2 【 分 子 量 】303.36692 |
【开发单位】Università degli Studi di Napoli (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Anesthetic Drugs, Local Anesthetics |
合成路线1
Condensation of 1,2,3-benzotriazin-4(3H)-one (I) with ethyl bromoacetate (II) in refluxing butanone afforded the 3-(ethoxycarbonylmethyl) derivative (III). The ethyl ester group of (III) was then converted into the target amide by reaction with N,N-diethylethylenediamine (IV) in hot MeOH
| 【1】 Caliendo, G.; De Nucci, G.; Meli, R.; Mattace Raso, G.; Fiorino, F.; Perissutti, E.; Zanesco, A.; Grieco, P.; Santagada, V.; Preparation and local anaesthetic activity of benzotriazinone and benzoyltriazole derivatives. Eur J Med Chem 1999, 34, 12, 1043. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36890 | 1,2,3-benzotriazin-4(3H)-one | C7H5N3O | 详情 | 详情 | |
| (II) | 16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 |
| (III) | 36891 | ethyl 2-[4-oxo-1,2,3-benzotriazin-3(4H)-yl]acetate | C11H11N3O3 | 详情 | 详情 | |
| (IV) | 12420 | N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine | 100-36-7 | C6H16N2 | 详情 | 详情 |
Extended Information