4-[[2,3-bis(nitrooxy)propoxy]methyl]phenol -Drug Synthesis Database

【结构式】

【分子编号】36607

【品名】4-[[2,3-bis(nitrooxy)propoxy]methyl]phenol

【CA登记号】

【分子式】C₁₀H₁₂N₂O₈

【分子量】288.21396

【元素组成】C 41.67% H 4.2% N 9.72% O 44.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Alkylation of 4-[2,3-dinitroxy)propoxymethyl]phenol (I) with epichlorhydrin (II) in the presence of NaOH provided the corresponding epoxypropoxy derivative (III). Then, epoxide opening with isopropylamine (IV) in refluxing MeOH furnished the desired amino alcohol.

参考文献中间体

合成目标

【1】 Prat Quinones, M.; Pi Sallent, J.; Vedrilla Veit, D. (Almirall Prodesfarma, SA); 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical compsn.. EP 0637583; JP 1995089910 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36607	4-[[2,3-bis(nitrooxy)propoxy]methyl]phenol		C₁₀H₁₂N₂O₈	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	36608	2-[(4-[[2,3-bis(nitrooxy)propoxy]methyl]phenoxy)methyl]oxirane; 4-[[2,3-bis(nitrooxy)propoxy]methyl]phenyl 2-oxiranylmethyl ether		C₁₃H₁₆N₂O₉	详情	详情
(IV)	23933	2-Propanamine; Isopropylamine	75-31-0	C₃H₉N	详情	详情

Extended Information