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【结 构 式】 
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【药物名称】PF-9404C, PF-9404 【化学名称】1-[4-[2(S),3-Bis(nitrooxy)propoxymethyl]phenoxy]-3-(isopropylamino)propan-2(S)-ol 【CA登记号】164340-32-3 (undefined isomer) 【 分 子 式 】C16H25N3O9 【 分 子 量 】403.39235 |
【开发单位】Almirall Prodesfarma (Originator) 【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Vasodilators, beta-Adrenoceptor Antagonists, Nitric Oxide Donors |
合成路线1
Alkylation of 4-[2,3-dinitroxy)propoxymethyl]phenol (I) with epichlorhydrin (II) in the presence of NaOH provided the corresponding epoxypropoxy derivative (III). Then, epoxide opening with isopropylamine (IV) in refluxing MeOH furnished the desired amino alcohol.
| 【1】 Prat Quinones, M.; Pi Sallent, J.; Vedrilla Veit, D. (Almirall Prodesfarma, SA); 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical compsn.. EP 0637583; JP 1995089910 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36607 | 4-[[2,3-bis(nitrooxy)propoxy]methyl]phenol | C10H12N2O8 | 详情 | 详情 | |
| (II) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
| (III) | 36608 | 2-[(4-[[2,3-bis(nitrooxy)propoxy]methyl]phenoxy)methyl]oxirane; 4-[[2,3-bis(nitrooxy)propoxy]methyl]phenyl 2-oxiranylmethyl ether | C13H16N2O9 | 详情 | 详情 | |
| (IV) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information