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【结 构 式】 
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【分子编号】41905 【品名】1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C29H28N2O6 【 分 子 量 】500.5512 【元素组成】C 69.59% H 5.64% N 5.6% O 19.18% |
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 5-methyl-5'-O-(triphenylmethyl)uridine (I) with MsCl and pyridine gives the dimesylate (II), which is treated with Li2Te in THF to yield the tritylated derivative (III) of the target compound.
| 【1】 Clive, D.L.J.; et al.; Synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides by reaction of 5'-protected nucleoside 2',3'-dimesylates with telluride dianion: A general route from cis vicinal diols to olefins. J Org Chem 1996, 61, 21, 7426. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41905 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C29H28N2O6 | 详情 | 详情 | |
| (II) | 41906 | 1-[(2R,3R,4R,5R)-3,4-bis[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C35H40N2O6S2 | 详情 | 详情 | |
| (III) | 12199 | 5-Methyl-1-[(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C29H26N2O4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)The reaction of 5-methyluridine (I) with TrCl and pyridine gives the 5'-O-trityl derivative (II), which is oxidized with NaIO4 in ethanol/water to yield the dialdehyde (III). The Wittig reaction of (III) with methyltriphenylphosphonium bromide (IV) and t-BuOK in toluene to afford the bis vinyl compound (V), which is submitted to a ring closing metathesis reaction catalyzed by a Ru catalyst in dichloromethane to provide the unsaturated nucleoside (VI). Finally, this compound is deprotected by means of AcOH in water to furnish the target Stavudine.
| 【1】 Ewing, D.F.; et al.; Synthesis of acyclic bis-vinyl pyrimidines: A general route to d4T via metathesis. Tetrahedron 2003, 59, 7, 941. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12206 | 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5-Methyluridine | 1463-10-1 | C10H14N2O6 | 详情 | 详情 |
| (II) | 41905 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C29H28N2O6 | 详情 | 详情 | |
| (III) | 62190 | (2R)-2-({(1R)-1-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-oxoethyl}oxy)-3-(trityloxy)propanal | C29H26N2O6 | 详情 | 详情 | |
| (IV) | 30484 | Methyl(triphenyl)phosphonium bromide | 1779-49-3 | C19H18BrP | 详情 | 详情 |
| (V) | 62191 | 5-methyl-1-[(1R)-1-({(1S)-1-[(trityloxy)methyl]-2-propenyl}oxy)-2-propenyl]-2,4(1H,3H)-pyrimidinedione | C31H30N2O4 | 详情 | 详情 | |
| (VI) | 12199 | 5-Methyl-1-[(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C29H26N2O4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(III)The reaction of 5-methyluridine (I) with trityl chloride (II) and pyridine gives the 5'-O-trityl analogue (III), which is submitted to an oxidative cleavage of the vicinal dihydroxy group by means of NaIO4 in EtOH/water to yield the dialdehyde (IV). The double Wittig olefination of (IV) by means of methyltriphenylphosphonium bromide (V) and t-BuOK in toluene affords the bis alkene (VI), which is submitted to a ring closing metathesis by means of the Grubb's catalyst in dichloromethane to provide the unsaturated nucleoside (VII). Finally, this compound was deprotected by means of 80% AcOH to furnish the target Stavudine.
| 【1】 Ewing, D.; Glacon, V.; Mackenzie, G.; Postel, D.; Len, C.; A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis. Tetrahedron Lett 2002, 43, 19, 3503. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12206 | 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5-Methyluridine | 1463-10-1 | C10H14N2O6 | 详情 | 详情 |
| (II) | 28630 | Triphenylchloromethane; 1-[Chloro(diphenyl)methyl]benzene; Trityl chloride | 76-83-5 | C19H15Cl | 详情 | 详情 |
| (III) | 41905 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C29H28N2O6 | 详情 | 详情 | |
| (IV) | 62190 | (2R)-2-({(1R)-1-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-oxoethyl}oxy)-3-(trityloxy)propanal | C29H26N2O6 | 详情 | 详情 | |
| (V) | 30484 | Methyl(triphenyl)phosphonium bromide | 1779-49-3 | C19H18BrP | 详情 | 详情 |
| (VI) | 62191 | 5-methyl-1-[(1R)-1-({(1S)-1-[(trityloxy)methyl]-2-propenyl}oxy)-2-propenyl]-2,4(1H,3H)-pyrimidinedione | C31H30N2O4 | 详情 | 详情 | |
| (VII) | 12199 | 5-Methyl-1-[(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione | C29H26N2O4 | 详情 | 详情 |