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【结 构 式】 
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【分子编号】36509 【品名】(methylsulfonyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate 【CA登记号】 |
【 分 子 式 】C53H61ClN2O13S 【 分 子 量 】1001.59172 【元素组成】C 63.56% H 6.14% Cl 3.54% N 2.8% O 20.77% S 3.2% |
合成路线1
该中间体在本合成路线中的序号：(XXII)The deprotection of the carbamate (XVIII) by means of TFA gives the free aminoester (XIX), which is reprotected with Fmoc-Cl and NaHCO3 yielding the acid (XX). The esterification of the hydroxy group of he intermediate (XVII) with the acid group of (XX) by means of EDC affords the expected ester (XXI). The oxidation of the methylsulfanyl group of (XXI) with oxone affords the corresponding methylsulfonylmethyl ester (XXII), which is cyclized by means of piperidine in DMF to give the macrocyclic epoxide (XXIII). Finally, this compound is treated with 12 N HCl in dimethoxyethane/water.
| 【1】 Zmijewski, M.J.J.; Zhang, T.Y.; Aikins, J.A.; Briggs, B.S. (Eli Lilly and Company; University of Hawaii; Wayne State University); Stereoselective process for producing antineoplastic agents. WO 0023429 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 36505 | (methylsulfanyl)methyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-([(E,5S,6S)-5-hydroxy-6-[(2R,3S)-3-phenyloxiranyl]-2-heptenoyl]amino)propanoate | C27H32ClNO6S | 详情 | 详情 | |
| (XVIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (XIX) | 36506 | (2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C11H21NO4 | 详情 | 详情 | |
| (XX) | 36507 | (2S)-2-[(3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C26H31NO6 | 详情 | 详情 | |
| (XXI) | 36508 | (methylsulfanyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O11S | 详情 | 详情 | |
| (XXII) | 36509 | (methylsulfonyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O13S | 详情 | 详情 | |
| (XXIII) | 63540 | (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-3-isobutyl-6,6-dimethyl-16-{(1R)-1-[(2R,3R)-3-phenyloxiranyl]ethyl}-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone | C36H45ClN2O8 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XXII)The deprotection of the carbamate (XVIII) by means of TFA gives the free aminoester (XIX), which is reprotected with Fmoc-Cl and NaHCO3 yielding the acid (XX). The esterification of the hydroxy group of he intermediate (XVII) with the acid group of (XX) by means of EDC affords the expected ester (XXI). The oxidation of the methylsulfanyl group of (XXI) with oxone affords the corresponding methylsulfonylmethyl ester (XXII), which is finally cyclized by means of piperidine in DMF.
| 【1】 Zmijewski, M.J.J.; Zhang, T.Y.; Aikins, J.A.; Briggs, B.S. (Eli Lilly and Company; University of Hawaii; Wayne State University); Stereoselective process for producing antineoplastic agents. WO 0023429 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 36505 | (methylsulfanyl)methyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-([(E,5S,6S)-5-hydroxy-6-[(2R,3S)-3-phenyloxiranyl]-2-heptenoyl]amino)propanoate | C27H32ClNO6S | 详情 | 详情 | |
| (XVIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (XIX) | 36506 | (2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C11H21NO4 | 详情 | 详情 | |
| (XX) | 36507 | (2S)-2-[(3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C26H31NO6 | 详情 | 详情 | |
| (XXI) | 36508 | (methylsulfanyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O11S | 详情 | 详情 | |
| (XXII) | 36509 | (methylsulfonyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O13S | 详情 | 详情 |