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【结 构 式】 
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【分子编号】18904 【品名】(2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid 【CA登记号】 |
【 分 子 式 】C16H29NO6 【 分 子 量 】331.4094 【元素组成】C 57.99% H 8.82% N 4.23% O 28.97% |
合成路线1
该中间体在本合成路线中的序号：(XVIII)The deprotection of the carbamate (XVIII) by means of TFA gives the free aminoester (XIX), which is reprotected with Fmoc-Cl and NaHCO3 yielding the acid (XX). The esterification of the hydroxy group of he intermediate (XVII) with the acid group of (XX) by means of EDC affords the expected ester (XXI). The oxidation of the methylsulfanyl group of (XXI) with oxone affords the corresponding methylsulfonylmethyl ester (XXII), which is cyclized by means of piperidine in DMF to give the macrocyclic epoxide (XXIII). Finally, this compound is treated with 12 N HCl in dimethoxyethane/water.
| 【1】 Zmijewski, M.J.J.; Zhang, T.Y.; Aikins, J.A.; Briggs, B.S. (Eli Lilly and Company; University of Hawaii; Wayne State University); Stereoselective process for producing antineoplastic agents. WO 0023429 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 36505 | (methylsulfanyl)methyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-([(E,5S,6S)-5-hydroxy-6-[(2R,3S)-3-phenyloxiranyl]-2-heptenoyl]amino)propanoate | C27H32ClNO6S | 详情 | 详情 | |
| (XVIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (XIX) | 36506 | (2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C11H21NO4 | 详情 | 详情 | |
| (XX) | 36507 | (2S)-2-[(3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C26H31NO6 | 详情 | 详情 | |
| (XXI) | 36508 | (methylsulfanyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O11S | 详情 | 详情 | |
| (XXII) | 36509 | (methylsulfonyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O13S | 详情 | 详情 | |
| (XXIII) | 63540 | (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-3-isobutyl-6,6-dimethyl-16-{(1R)-1-[(2R,3R)-3-phenyloxiranyl]ethyl}-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone | C36H45ClN2O8 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)Title compound can be prepared either by bacterial fermentation or by chemical synthesis. Thus, the compund was isolated from cultures of Nostoc sp. GSV 224, growing in the presence of 2,2-dimethyl-b-alanine. After lyophilization and extraction with CH3CN-CH2Cl2, the extract was subjected to several chromatographic purifications to provide the pure compound. Alternatively, 2,2-dimethyl-b-alanine tert-butyl ester (I) was deprotected with trifluoroacetic acid, and the resulting carboxylic acid (II) was treated with di tert-butyl oxalate (III) in the presence of NaOH to afford carbamate (IV). Subsequent coupling with allyl (S)-2-hydroxy-4-methylpentanoate (V) using DCC and DMAP gave ester (VI). The allyl ester was then cleaved by treatment with Pd(Ph3P)4 and morpholine in THF at r.t., and the resulting acid (VII) was coupled with compound (VIII) in the presence of DCC and DMAP to afford (IX). After deprotection of the trichloroethyl ester group by treatment with Zn in AcOH and subsequent cleavage of the N-Boc group with trifluoroacetic acid, the resulting amino acid compound (XI) was cyclized using pentafluorophenyl diphenyl phosphinate (FDPP) to furnish (XII). Finally, epoxidation with meta-chloroperbenzoic acid provided a mixture of diastereomeric epoxides that were separated by reverse phase HPLC.
| 【1】 Shih, C.; Gossett, L.S.; Gruber, J.M.; Grossman, C.S.; Andis, S.L.; Schultz, R.M.; Worzalla, J.F.; Corbett, T.H.; Metz, J.T.; Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region. Bioorg Med Chem Lett 1999, 9, 1, 69. |
| 【2】 Moore, R.E.; Patel, V.F.; Ray, J.E.; Toth, J.E. (Eli Lilly and Company; University of Hawaii; Wayne State University); Pharmaceutical cpds.. EP 0850057; JP 2000501067; WO 9707798; WO 9708334 . |
| 【3】 Shih, C. (Eli Lilly and Company; University of Hawaii; Wayne State University); Pharmaceutical cpds.. EP 0869786; JP 2000502351; WO 9723211 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18898 | tert-butyl 3-amino-2,2-dimethylpropanoate | C9H19NO2 | 详情 | 详情 | |
| (II) | 18899 | 2,2-dimethyl-beta-alanine | C5H11NO2 | 详情 | 详情 | |
| (III) | 18900 | tert-butyl 2-(tert-butoxy)-2-oxoacetate | C10H18O4 | 详情 | 详情 | |
| (IV) | 18901 | N-(tert-butoxycarbonyl)-2,2-dimethyl-beta-alanine | C10H19NO4 | 详情 | 详情 | |
| (V) | 18902 | allyl (2S)-2-hydroxy-4-methylpentanoate | C9H16O3 | 详情 | 详情 | |
| (VI) | 18903 | allyl (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoate | C19H33NO6 | 详情 | 详情 | |
| (VII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (VIII) | 18905 | 2,2,2-trichloroethyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-[[(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl]amino]propanoate | C27H29Cl4NO5 | 详情 | 详情 | |
| (IX) | 18906 | 2,2,2-trichloroethyl (10S,13S,15E,19R)-19-(3-chloro-4-methoxybenzyl)-10-isobutyl-2,2,7,7-tetramethyl-13-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-4,8,11,17-tetraoxo-3,9,12-trioxa-5,18-diaza-15-icosen-20-oate | C43H56Cl4N2O10 | 详情 | 详情 | |
| (X) | 18907 | (10S,13S,15E,19R)-19-(3-chloro-4-methoxybenzyl)-10-isobutyl-2,2,7,7-tetramethyl-13-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-4,8,11,17-tetraoxo-3,9,12-trioxa-5,18-diaza-15-icosen-20-oic acid | C41H55ClN2O10 | 详情 | 详情 | |
| (XI) | 18908 | (2R)-2-[[(2E,5S,6R,7E)-5-([(2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoyl]oxy)-6-methyl-8-phenyl-2,7-octadienoyl]amino]-3-(3-chloro-4-methoxyphenyl)propionic acid | C36H47ClN2O8 | 详情 | 详情 | |
| (XII) | 18909 | (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-3-isobutyl-6,6-dimethyl-16-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone | C36H45ClN2O7 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XVIII)The deprotection of the carbamate (XVIII) by means of TFA gives the free aminoester (XIX), which is reprotected with Fmoc-Cl and NaHCO3 yielding the acid (XX). The esterification of the hydroxy group of he intermediate (XVII) with the acid group of (XX) by means of EDC affords the expected ester (XXI). The oxidation of the methylsulfanyl group of (XXI) with oxone affords the corresponding methylsulfonylmethyl ester (XXII), which is finally cyclized by means of piperidine in DMF.
| 【1】 Zmijewski, M.J.J.; Zhang, T.Y.; Aikins, J.A.; Briggs, B.S. (Eli Lilly and Company; University of Hawaii; Wayne State University); Stereoselective process for producing antineoplastic agents. WO 0023429 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 36505 | (methylsulfanyl)methyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-([(E,5S,6S)-5-hydroxy-6-[(2R,3S)-3-phenyloxiranyl]-2-heptenoyl]amino)propanoate | C27H32ClNO6S | 详情 | 详情 | |
| (XVIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (XIX) | 36506 | (2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C11H21NO4 | 详情 | 详情 | |
| (XX) | 36507 | (2S)-2-[(3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,2-dimethylpropanoyl)oxy]-4-methylpentanoic acid | C26H31NO6 | 详情 | 详情 | |
| (XXI) | 36508 | (methylsulfanyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O11S | 详情 | 详情 | |
| (XXII) | 36509 | (methylsulfonyl)methyl (9S,12S,14E,18R)-18-(3-chloro-4-methoxybenzyl)-1-(9H-fluoren-9-yl)-9-isobutyl-6,6-dimethyl-3,7,10,16-tetraoxo-12-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-2,8,11-trioxa-4,17-diaza-14-nonadecen-19-oate | C53H61ClN2O13S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VIII)Synthesis of intermediate 2(S)-[3-(tert-butoxycarbonylamino)-2,2-dimethylpropionyloxy]-4-methylpentanoic acid (VIII): The reaction of 3-amino-2,2-dimethyl-1-propanol (I) with Boc2 and Et3N in methanol gives the carbamate (II), which is oxidized with NaIO4 in CCl4/acetonitrile/water yielding 3-(tert-butoxycarbonylamino)-2,2-dimethylpropionic acid (III). The esterification of 2(S)-hydroxy-4-methylpentanoic acid (IV) with allyl bromide (V), NaHCO3 and tetrabutylammonium chloride in dichloromethane/water affords the corresponding allyl ester (VI). The esterification of hydroxyester (VI) with amino acid (II) by means of DCC and DMAP in dichloromethane provides the corresponding diester (VII), which is finally treated with Pd(PPh3)4 and morpholine in THF to furnish the intermediate 2(S)-[3-(tert-butoxycarbonylamino)-2,2-dimethylpropionyloxy]-4-methylpentanoic acid (VIII).
| 【1】 WO 9640184 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42783 | 3-amino-2,2-dimethyl-1-propanol | 26734-09-8 | C5H13NO | 详情 | 详情 |
| (II) | 42784 | tert-butyl 3-hydroxy-2,2-dimethylpropylcarbamate | C10H21NO3 | 详情 | 详情 | |
| (III) | 18901 | N-(tert-butoxycarbonyl)-2,2-dimethyl-beta-alanine | C10H19NO4 | 详情 | 详情 | |
| (IV) | 42785 | (2S)-2-hydroxy-4-methylpentanoic acid | 13748-90-8 | C6H12O3 | 详情 | 详情 |
| (V) | 11720 | 4-Bromo-1-butene | 5162-44-7 | C4H7Br | 详情 | 详情 |
| (VI) | 18902 | allyl (2S)-2-hydroxy-4-methylpentanoate | C9H16O3 | 详情 | 详情 | |
| (VII) | 18903 | allyl (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoate | C19H33NO6 | 详情 | 详情 | |
| (VIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(VIII)Synthesis of 261501: The optical resolution of trans-3-penten-2-ol (IX) with porcine pancreatic lipase (PPL) and trifluoroethyl laurate in ethyl ether gives the (S)-trans-isomer (X), which is condensed with propargyl alcohol (XI) by means of tetrabutylammonium hyrogensulfate and NaOH in water, yielding the corresponding ether (XII). Rearrangement of (XII) by means of BuLi in THF affords (3R,4R,5E)-4-methylhept-5-en-1-yn-3-ol (XIII), which is silylated with Tbdms-Cl and imidazole to afford the corresponding silyl ether (XIV). The reaction of (XIV) with BH3 in THF provides the aldehyde (XV), which is condensed with phosphonate (XVI) by means of tetramethylguanidine (TMG) in THF to give the nonadienoic ester (XVII). Ozonolysis of (XVII), followed by reaction with Zn/HOAc yields the aldehyde (XVIII), which is condensed with benzyltriphenylphosphonium chloride (XIX) by means of BuLi in THF to afford the 8-phenyloctadienoic ester (XX). The hydrolysis of (XX) with LiOH in acetone/water furnishes the corresponding free acid (XXI), which is condensed with 3-chloro-4-methoxy-L-phenylalanine trichloroethyl ester (XXII) by means of pentafluorodiphenylphosphinate (FDPP) and DIEA in DMF to give the corresponding amide (XXIII). The desilylation of (XXIII) with aqueous HF in acetonitrile affords the hydroxyamide (XXIV), which is esterified with the intermediate 2(S)-[3-(tert-butoxycarbonylamino)-2,2-dimethylpropionyloxy]-4-methylpentanoic acid (VIII) by means of DCC and DMAP in dichloromethane gives the corresponding ester (XXV).
| 【1】 WO 9640184 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIII) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (IX) | 42786 | (E)-3-penten-2-ol | C5H10O | 详情 | 详情 | |
| (X) | 42787 | (2S,3E)-3-penten-2-ol | C5H10O | 详情 | 详情 | |
| (XI) | 16664 | Propargyl Alcohol; 2-propyn-1-ol | 107-19-7 | C3H4O | 详情 | 详情 |
| (XII) | 42788 | (1S,2E)-1-methyl-2-butenyl 2-propynyl ether; (E,4S)-4-(2-propynyloxy)-2-pentene | C8H12O | 详情 | 详情 | |
| (XIII) | 42789 | (3R,4R,5E)-4-methyl-5-hepten-1-yn-3-ol | C8H12O | 详情 | 详情 | |
| (XIV) | 42790 | tert-butyl(dimethyl)silyl (1R,2R,3E)-1-ethynyl-2-methyl-3-pentenyl ether; tert-butyl[[(1R,2R,3E)-1-ethynyl-2-methyl-3-pentenyl]oxy]dimethylsilane | C14H26OSi | 详情 | 详情 | |
| (XV) | 42791 | (3S,4R,5E)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-methyl-5-heptenal | C14H28O2Si | 详情 | 详情 | |
| (XVI) | 27698 | methyl 2-(diethoxyphosphoryl)acetate | 1067-74-9 | C7H15O5P | 详情 | 详情 |
| (XVII) | 42792 | methyl (2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-2,7-nonadienoate | C17H32O3Si | 详情 | 详情 | |
| (XVIII) | 42793 | methyl (E,5S,6S)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-7-oxo-2-heptenoate | C15H28O4Si | 详情 | 详情 | |
| (XIX) | 42794 | Benzyl(triphenyl)phosphonium chloride | 1449-46-3 | C25H22ClP | 详情 | 详情 |
| (XX) | 34373 | methyl (2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-8-phenyl-2,7-octadienoate | C22H34O3Si | 详情 | 详情 | |
| (XXI) | 34374 | (2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-8-phenyl-2,7-octadienoic acid | C21H32O3Si | 详情 | 详情 | |
| (XXII) | 42795 | 2,2,2-trichloroethyl (2R)-2-amino-3-(3-chloro-4-methoxyphenyl)propanoate | C12H13Cl4NO3 | 详情 | 详情 | |
| (XXIII) | 42796 | 2,2,2-trichloroethyl (2R)-2-[((2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-8-phenyl-2,7-octadienoyl)amino]-3-(3-chloro-4-methoxyphenyl)propanoate | C33H43Cl4NO5Si | 详情 | 详情 | |
| (XXIV) | 18905 | 2,2,2-trichloroethyl (2R)-3-(3-chloro-4-methoxyphenyl)-2-[[(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl]amino]propanoate | C27H29Cl4NO5 | 详情 | 详情 | |
| (XXV) | 18906 | 2,2,2-trichloroethyl (10S,13S,15E,19R)-19-(3-chloro-4-methoxybenzyl)-10-isobutyl-2,2,7,7-tetramethyl-13-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-4,8,11,17-tetraoxo-3,9,12-trioxa-5,18-diaza-15-icosen-20-oate | C43H56Cl4N2O10 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(IX)The known methyl ester (VI was hydrolyzed to carboxylic acid (VII) with LiOH in aqueous acetone. After conversion of (VII) to the corresponding succinimidyl ester with N-hydroxysuccinimide and EDC, fluoride-mediated desilylation under acidic conditions furnished alcohol (VIII). Subsequent esterification of (VIII) with the protected amino acid (IX) using EDC and a catalytic amount of DMAP provided intermediate (X). Then, chemoselective coupling of (X) with amino acid (V) was achieved in the presence of N,O-bis(trimethylsilyl)acetamide (BSA) in hot DMF to afford the acyclic precursor (XI). After removal of the Boc group of (XI) with trifluoroacetic acid, the resulting amino acid (XII) was converted to the cyclic depsipeptide (XIII) by macrolactonization under high dilution conditions in the presence of pentafluorophenyl diphenylphosphinate. The aryl amine of (XIII) was protected as the Fmoc derivative (XIV).
| 【1】 Schultz, R.M.; Andis, S.L.; Ray, J. E.; Patel, V.F.; Kennedy, J.H.; Novel cryptophycin antitumor agents: Synthesis and cytotoxicity of fragment "B" analogues. J Med Chem 1999, 42, 14, 2588. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 40597 | 9-[[(chlorocarbonyl)oxy]methyl]-9H-fluorene | 28920-43-6 | C15H11ClO2 | 详情 | 详情 | |
| (V) | 34372 | (2R)-2-amino-3-(4-amino-3-chlorophenyl)propionic acid | C9H11ClN2O2 | 详情 | 详情 | |
| (VI) | 34373 | methyl (2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-8-phenyl-2,7-octadienoate | C22H34O3Si | 详情 | 详情 | |
| (VII) | 34374 | (2E,5S,6R,7E)-5-[[tert-butyl(dimethyl)silyl]oxy]-6-methyl-8-phenyl-2,7-octadienoic acid | C21H32O3Si | 详情 | 详情 | |
| (VIII) | 34375 | 1-[[(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl]oxy]-2,5-pyrrolidinedione | C19H21NO5 | 详情 | 详情 | |
| (IX) | 18904 | (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoic acid | C16H29NO6 | 详情 | 详情 | |
| (X) | 34376 | (1S,3E)-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-5-oxo-3-pentenyl (2S)-2-([3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl]oxy)-4-methylpentanoate | C35H48N2O10 | 详情 | 详情 | |
| (XI) | 34377 | (10S,13S,15E,19R)-19-(4-amino-3-chlorobenzyl)-10-isobutyl-2,2,7,7-tetramethyl-13-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-4,8,11,17-tetraoxo-3,9,12-trioxa-5,18-diaza-15-icosen-20-oic acid | C40H54ClN3O9 | 详情 | 详情 | |
| (XII) | 34378 | (2R)-3-(4-amino-3-chlorophenyl)-2-[[(2E,5S,6R,7E)-5-([(2S)-2-[(3-amino-2,2-dimethylpropanoyl)oxy]-4-methylpentanoyl]oxy)-6-methyl-8-phenyl-2,7-octadienoyl]amino]propionic acid | C35H46ClN3O7 | 详情 | 详情 | |
| (XIII) | 34379 | (3S,10R,16S)-10-(4-amino-3-chlorobenzyl)-3-isobutyl-6,6-dimethyl-16-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone | C35H44ClN3O6 | 详情 | 详情 | |
| (XIV) | 34380 | 9H-fluoren-9-ylmethyl 2-chloro-4-([(3S,10R,16S)-3-isobutyl-6,6-dimethyl-16-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-13-cyclohexadecen-10-yl]methyl)phenylcarbamate | C50H54ClN3O8 | 详情 | 详情 |