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【结 构 式】 
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【分子编号】36306 【品名】diacetyl [7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl]carbonyl borate 【CA登记号】 |
【 分 子 式 】C23H26BF2N3O8 【 分 子 量 】521.2826664 【元素组成】C 52.99% H 5.03% B 2.07% F 7.29% N 8.06% O 24.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIIb)In a further procedure, the deprotected pyrrolidine (XIII) was condensed with the fluoroquinoline (XIV) to give (XVII). The boron chelate of (XVII) was then deprotected with Et3N in EtOH-H2O at 50 C.
| 【1】 Takeda, T.; Kimura, K.; Ohki, H.; Takahashi, H.; Miyauchi, R.; Takemura, M. (Daiichi Pharmaceutical Co., Ltd.); Cis-substd. fluoromethylpyrrolidine derivs.. EP 0995744; WO 9858923 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIVa) | 36300 | 1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6,7-difluoro-8-methoxy-4(1H)-quinolinone | C14H10BF4NO4 | 详情 | 详情 | |
| (XIVb) | 36301 | diacetyl (1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl)carbonyl borate | C18H16BF2NO8 | 详情 | 详情 | |
| (XVIIa) | 36305 | 7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6-fluoro-8-methoxy-4(1H)-quinolinone | C19H20BF4N3O4 | 详情 | 详情 | |
| (XVIIb) | 36306 | diacetyl [7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl]carbonyl borate | C23H26BF2N3O8 | 详情 | 详情 | |
| (XIII) | 36299 | (3S,4S)-4-(fluoromethyl)-3-pyrrolidinamine; (3S,4S)-4-(fluoromethyl)pyrrolidinylamine | C5H11FN2 | 详情 | 详情 |
Extended Information