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【结 构 式】

【分子编号】36306

【品名】diacetyl [7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl]carbonyl borate

【CA登记号】

【 分 子 式 】C23H26BF2N3O8

【 分 子 量 】521.2826664

【元素组成】C 52.99% H 5.03% B 2.07% F 7.29% N 8.06% O 24.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVIIb)

In a further procedure, the deprotected pyrrolidine (XIII) was condensed with the fluoroquinoline (XIV) to give (XVII). The boron chelate of (XVII) was then deprotected with Et3N in EtOH-H2O at 50 C.

1 Takeda, T.; Kimura, K.; Ohki, H.; Takahashi, H.; Miyauchi, R.; Takemura, M. (Daiichi Pharmaceutical Co., Ltd.); Cis-substd. fluoromethylpyrrolidine derivs.. EP 0995744; WO 9858923 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIVa) 36300 1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6,7-difluoro-8-methoxy-4(1H)-quinolinone C14H10BF4NO4 详情 详情
(XIVb) 36301 diacetyl (1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl)carbonyl borate C18H16BF2NO8 详情 详情
(XVIIa) 36305 7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6-fluoro-8-methoxy-4(1H)-quinolinone C19H20BF4N3O4 详情 详情
(XVIIb) 36306 diacetyl [7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl]carbonyl borate C23H26BF2N3O8 详情 详情
(XIII) 36299 (3S,4S)-4-(fluoromethyl)-3-pyrrolidinamine; (3S,4S)-4-(fluoromethyl)pyrrolidinylamine C5H11FN2 详情 详情
Extended Information