7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6-fluoro-8-methoxy-4(1H)-quinolinone -Drug Synthesis Database

【结构式】

【分子编号】36305

【品名】7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6-fluoro-8-methoxy-4(1H)-quinolinone

【CA登记号】

【分子式】C₁₉H₂₀BF₄N₃O₄

【分子量】441.1902328

【元素组成】C 51.73% H 4.57% B 2.45% F 17.22% N 9.52% O 14.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVIIa)

In a further procedure, the deprotected pyrrolidine (XIII) was condensed with the fluoroquinoline (XIV) to give (XVII). The boron chelate of (XVII) was then deprotected with Et3N in EtOH-H2O at 50 C.

参考文献中间体

合成目标

【1】 Takeda, T.; Kimura, K.; Ohki, H.; Takahashi, H.; Miyauchi, R.; Takemura, M. (Daiichi Pharmaceutical Co., Ltd.); Cis-substd. fluoromethylpyrrolidine derivs.. EP 0995744; WO 9858923 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XIVa)	36300	1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6,7-difluoro-8-methoxy-4(1H)-quinolinone	C₁₄H₁₀BF₄NO₄	详情	详情
(XIVb)	36301	diacetyl (1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl)carbonyl borate	C₁₈H₁₆BF₂NO₈	详情	详情
(XVIIa)	36305	7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-3-[[(difluoroboryl)oxy]carbonyl]-6-fluoro-8-methoxy-4(1H)-quinolinone	C₁₉H₂₀BF₄N₃O₄	详情	详情
(XVIIb)	36306	diacetyl [7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidinyl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinyl]carbonyl borate	C₂₃H₂₆BF₂N₃O₈	详情	详情
(XIII)	36299	(3S,4S)-4-(fluoromethyl)-3-pyrrolidinamine; (3S,4S)-4-(fluoromethyl)pyrrolidinylamine	C₅H₁₁FN₂	详情	详情

Extended Information