2-(1H-imidazol-1-yl)-1-(4-phenethylphenyl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】36216

【品名】2-(1H-imidazol-1-yl)-1-(4-phenethylphenyl)-1-ethanone

【CA登记号】

【分子式】C₁₉H₁₈N₂O

【分子量】290.3648

【元素组成】C 78.59% H 6.25% N 9.65% O 5.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of imidazole (I) with 4-(phenethyl)phenacyl chloride (II) in DMF gives 1-[4-(phenethyl)phenacyl]imidazole (III), which is then reduced with NaBH4 in refluxing methanol.

参考文献中间体

合成目标

【1】 Pennini, R.; Tajana, A.; Magistretti, M.J.; Portioli, F.; Nardi, D.; Leonardi, A.; Subissi, A.; Synthesis and anticonvulsant avtivity of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles. J Med Chem 1981, 24, 6, 727-731.
【2】 Nardi, D.; Tajana, A.; Magistretti, M.J. (Recordati Industria Chimica e Farmaceutica SpA); Imidazole derivs.. DE 2929777 .
【3】 Castaner, J.; Serradell, M.N.; Blancafort, P.; de Angelis, L.; Denzimol. Drugs Fut 1983, 8, 11, 915.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情
(II)	36215	2-chloro-1-(4-phenethylphenyl)-1-ethanone		C₁₆H₁₅ClO	详情	详情
(III)	36216	2-(1H-imidazol-1-yl)-1-(4-phenethylphenyl)-1-ethanone		C₁₉H₁₈N₂O	详情	详情

Extended Information