Denzimol, Rec-151533, -Drug Synthesis Database

【结构式】

【药物名称】Denzimol, Rec-151533

【化学名称】(±)-1-[(4-Phenethyl)phenyl]-2-(N-imidazolyl)ethanol
　　　　　　(±)-alpha-(p-Phenethylphenyl)imidazole-1-ethanol
　　　　　　(±)-alpha-[4-(2-Phenylethyl)phenyl]-1H-imidazole-1-ethanol

【CA登记号】73931-96-1

【分子式】C₁₉H₂₀N₂O

【分子量】292.38405

【开发单位】Recordati (Originator)

【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS

合成路线1

The condensation of imidazole (I) with 4-(phenethyl)phenacyl chloride (II) in DMF gives 1-[4-(phenethyl)phenacyl]imidazole (III), which is then reduced with NaBH4 in refluxing methanol.

参考文献中间体

【1】 Pennini, R.; Tajana, A.; Magistretti, M.J.; Portioli, F.; Nardi, D.; Leonardi, A.; Subissi, A.; Synthesis and anticonvulsant avtivity of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles. J Med Chem 1981, 24, 6, 727-731.
【2】 Nardi, D.; Tajana, A.; Magistretti, M.J. (Recordati Industria Chimica e Farmaceutica SpA); Imidazole derivs.. DE 2929777 .
【3】 Castaner, J.; Serradell, M.N.; Blancafort, P.; de Angelis, L.; Denzimol. Drugs Fut 1983, 8, 11, 915.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情
(II)	36215	2-chloro-1-(4-phenethylphenyl)-1-ethanone		C₁₆H₁₅ClO	详情	详情
(III)	36216	2-(1H-imidazol-1-yl)-1-(4-phenethylphenyl)-1-ethanone		C₁₉H₁₈N₂O	详情	详情

Extended Information