【结 构 式】 |
【分子编号】36015 【品名】5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinamine; 5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinylamine 【CA登记号】 |
【 分 子 式 】C15H20ClN3 【 分 子 量 】277.79672 【元素组成】C 64.85% H 7.26% Cl 12.76% N 15.13% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)The cyclization of ethyl 2-(1-adamantyl)acetoacetate (I) with guanidine (II) gives 2-amino-4-hydroxy-5-(1-adamantyl)-6-methylpyrimidine (III), which by treatment with PCl5 in refluxing POCl3 is converted into 2-amino-4-chloro-5-(1-adamantyl)-6-methylpyrimidine (IV). Finally, this compound is treated with NH3 in ethanol, and with ethanesulfonic acid.
【1】 Jonak, J.P.; Mead, L.H.; Zakrzewski, S.F.; Synthesis and biological activity of some 5-substituted 2,4-diamino-6-alkylpyrimidines. J Med Chem 1972, 15, 6, 662-665. |
【2】 Mead, L.H.; Jonak, J.P.; Zakrzewski, S.F.; Synthesis and biological activity of some 5-(1-adamantyl)pyrimidines. J Med Chem 1971, 14, 5, 408-411. |
【3】 Blancafort, P.; Serradell, M.N.; Hopkins, S.J.; Castaner, J.; DAMP-ES. Drugs Fut 1983, 8, 4, 310. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 36013 | ethyl 2-(1-adamantyl)-3-oxobutanoate | C16H24O3 | 详情 | 详情 | |
(II) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
(III) | 36014 | 5-(1-adamantyl)-2-amino-6-methyl-4-pyrimidinol | C15H21N3O | 详情 | 详情 | |
(IV) | 36015 | 5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinamine; 5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinylamine | C15H20ClN3 | 详情 | 详情 |
Extended Information