|
【结 构 式】 
|
【药物名称】DAMP-ES 【化学名称】5-(1-Adamantyl)-2,4-diamino-6-methylpyrimidine ethanesulfonate salt 【CA登记号】78825-25-9, 31935-08-7 (free base) 【 分 子 式 】C17H28N4O3S 【 分 子 量 】368.50171 |
【开发单位】Roswell Park Memorial Inst. (Originator) 【药理作用】ONCOLYTIC DRUGS, Dihydrofolate Reductase (DHFR) Inhibitors |
合成路线1
The cyclization of ethyl 2-(1-adamantyl)acetoacetate (I) with guanidine (II) gives 2-amino-4-hydroxy-5-(1-adamantyl)-6-methylpyrimidine (III), which by treatment with PCl5 in refluxing POCl3 is converted into 2-amino-4-chloro-5-(1-adamantyl)-6-methylpyrimidine (IV). Finally, this compound is treated with NH3 in ethanol, and with ethanesulfonic acid.
| 【1】 Jonak, J.P.; Mead, L.H.; Zakrzewski, S.F.; Synthesis and biological activity of some 5-substituted 2,4-diamino-6-alkylpyrimidines. J Med Chem 1972, 15, 6, 662-665. |
| 【2】 Mead, L.H.; Jonak, J.P.; Zakrzewski, S.F.; Synthesis and biological activity of some 5-(1-adamantyl)pyrimidines. J Med Chem 1971, 14, 5, 408-411. |
| 【3】 Blancafort, P.; Serradell, M.N.; Hopkins, S.J.; Castaner, J.; DAMP-ES. Drugs Fut 1983, 8, 4, 310. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36013 | ethyl 2-(1-adamantyl)-3-oxobutanoate | C16H24O3 | 详情 | 详情 | |
| (II) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
| (III) | 36014 | 5-(1-adamantyl)-2-amino-6-methyl-4-pyrimidinol | C15H21N3O | 详情 | 详情 | |
| (IV) | 36015 | 5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinamine; 5-(1-adamantyl)-4-chloro-6-methyl-2-pyrimidinylamine | C15H20ClN3 | 详情 | 详情 |
Extended Information