5-methyl-10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol -Drug Synthesis Database

【结构式】

【分子编号】35931

【品名】5-methyl-10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol

【CA登记号】

【分子式】C₂₁H₂₃NO

【分子量】305.41976

【元素组成】C 82.59% H 7.59% N 4.59% O 5.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Intermediate (III) can be obtained as follows: The reaction of (I) with piperidine (B) by means of potassium tertbutoxide in refluxing tert-butanol gives 10-(1-piperidyl)-5H-dibenzo[a,d]cyclohepten-5-one (XII), which by reaction with methyllithium in ether is converted into 5-hydroxy-5-methyl-10-(1-piperidyl)-5H-dibenzo[a,d]cycloheptene (XIII). Finally, the dehydration of (XIII) in refluxing ethanolic HCl yields (III), already obtained.

参考文献中间体

合成目标

【1】 Anderson, P.S.; Christy, M.E.; Evans, B.E.; ES 473492 .
【2】 Thorpe, P.J.; Castaner, J.; Serradell, M.N.; Blancafort, P.; MK-801. Drugs Fut 1983, 8, 2, 120.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	10158	Piperidine	110-89-4	C₅H₁₁N	详情	详情
(I)	35924	10-bromo-5H-dibenzo[a,d]cyclohepten-5-one		C₁₅H₉BrO	详情	详情
(III)	35926	5-methylene-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one		C₁₆H₁₂O	详情	详情
(XII)	35930	10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-one		C₂₀H₁₉NO	详情	详情
(XIII)	35931	5-methyl-10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol		C₂₁H₂₃NO	详情	详情

Extended Information