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【结 构 式】

【分子编号】35930

【品名】10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-one

【CA登记号】

【 分 子 式 】C20H19NO

【 分 子 量 】289.377

【元素组成】C 83.01% H 6.62% N 4.84% O 5.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XII)

Intermediate (III) can be obtained as follows: The reaction of (I) with piperidine (B) by means of potassium tertbutoxide in refluxing tert-butanol gives 10-(1-piperidyl)-5H-dibenzo[a,d]cyclohepten-5-one (XII), which by reaction with methyllithium in ether is converted into 5-hydroxy-5-methyl-10-(1-piperidyl)-5H-dibenzo[a,d]cycloheptene (XIII). Finally, the dehydration of (XIII) in refluxing ethanolic HCl yields (III), already obtained.

1 Anderson, P.S.; Christy, M.E.; Evans, B.E.; ES 473492 .
2 Thorpe, P.J.; Castaner, J.; Serradell, M.N.; Blancafort, P.; MK-801. Drugs Fut 1983, 8, 2, 120.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 10158 Piperidine 110-89-4 C5H11N 详情 详情
(I) 35924 10-bromo-5H-dibenzo[a,d]cyclohepten-5-one C15H9BrO 详情 详情
(III) 35926 5-methylene-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one C16H12O 详情 详情
(XII) 35930 10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-one C20H19NO 详情 详情
(XIII) 35931 5-methyl-10-(1-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol C21H23NO 详情 详情
Extended Information