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【结 构 式】

【分子编号】35821

【品名】1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-amine; 1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-ylamine

【CA登记号】

【 分 子 式 】C13H9ClN4O2S

【 分 子 量 】320.75892

【元素组成】C 48.68% H 2.83% Cl 11.05% N 17.47% O 9.98% S 10%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of 2-nitro-5-chlorophenylhydrazine (I) with cyanoaldehyde (II) afforded the aminopyrazole derivative (III). This was then cyclized to the target benzotriazine system upon treatment with aqueous NaOH.

1 Bruni, F.; Malmberg Aiello, P.; Guerrini, G.; Martini, C.; Ipponi, A.; Costanzo, A.; Ciciani, G.; Costa, B.; Luccchini, A.; Selleri, S.; Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2, 4]benzotriazine 5-oxides. J Med Chem 1999, 42, 12, 2218.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 35819 1-(5-chloro-2-nitrophenyl)hydrazine C6H6ClN3O2 详情 详情
(II) 35820 3-oxo-2-(3-thienyl)propanenitrile C7H5NOS 详情 详情
(III) 35821 1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-amine; 1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-ylamine C13H9ClN4O2S 详情 详情
Extended Information