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【结 构 式】 
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【药物名称】GG-121 【化学名称】8-Chloro-3-(3-thienyl)pyrazolo[5,1-c][1,2,4]benzotriazine-5-oxide 【CA登记号】 【 分 子 式 】C13H7ClN4OS 【 分 子 量 】302.74394 |
【开发单位】Università degli Studi di Firenze (Originator), Università degli Studi di Pisa (Originator) 【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS, GABA(A) Receptor Agonists |
合成路线1
Condensation of 2-nitro-5-chlorophenylhydrazine (I) with cyanoaldehyde (II) afforded the aminopyrazole derivative (III). This was then cyclized to the target benzotriazine system upon treatment with aqueous NaOH.
| 【1】 Bruni, F.; Malmberg Aiello, P.; Guerrini, G.; Martini, C.; Ipponi, A.; Costanzo, A.; Ciciani, G.; Costa, B.; Luccchini, A.; Selleri, S.; Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2, 4]benzotriazine 5-oxides. J Med Chem 1999, 42, 12, 2218. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35819 | 1-(5-chloro-2-nitrophenyl)hydrazine | C6H6ClN3O2 | 详情 | 详情 | |
| (II) | 35820 | 3-oxo-2-(3-thienyl)propanenitrile | C7H5NOS | 详情 | 详情 | |
| (III) | 35821 | 1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-amine; 1-(5-chloro-2-nitrophenyl)-4-(3-thienyl)-1H-pyrazol-5-ylamine | C13H9ClN4O2S | 详情 | 详情 |
Extended Information