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【结 构 式】 
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【分子编号】35749 【品名】2-chloro-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine; 4-[2-chloro-5-(trifluoromethyl)-3-pyridinyl]phenyl methyl sulfone 【CA登记号】 |
【 分 子 式 】C13H9ClF3NO2S 【 分 子 量 】335.7339096 【元素组成】C 46.51% H 2.7% Cl 10.56% F 16.98% N 4.17% O 9.53% S 9.55% |
合成路线1
该中间体在本合成路线中的序号：(XI)Bromination of 2-amino-5-trifluoromethylpyridine (V) in AcOH provided bromopyridine (VI), which was submitted to a Suzuki coupling with 4-(methylthio)benzeneboronic acid (VII) yielding the phenylpyridine derivative (VIII). Oxidation of the methylthio group of (VIII) to the corresponding sulfone (IX) was carried out by treatment with N-methylmorpholine-N-oxide in the presence of OsO4. Diazotization of the amino group of (IX) generated the pyridone (X), and further chlorination employing POCl3 provided chloropyridine (XI). Finally, condensation of (XI) with (S)-2-mercaptopropanol (IV) yielded the title compound.
| 【1】 Friesen, R.W.; Deschênes, D.; Gordon, R.; Brideau, C.; Riendau, D.; Savoie, C.; Dubé, D.; Girard, Y.; Fortin, R.; Chan, C.-C.; 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 1999, 9, 12, 1715. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 35743 | (2S)-2-sulfanyl-1-propanol | C3H8OS | 详情 | 详情 | |
| (V) | 35744 | 5-(trifluoromethyl)-2-pyridinylamine; 5-(trifluoromethyl)-2-pyridinamine | 74784-70-6 | C6H5F3N2 | 详情 | 详情 |
| (VI) | 35745 | 3-bromo-5-(trifluoromethyl)-2-pyridinamine; 3-bromo-5-(trifluoromethyl)-2-pyridinylamine | C6H4BrF3N2 | 详情 | 详情 | |
| (VII) | 18561 | 4-(methylsulfanyl)phenylboronic acid | 98546-51-1 | C7H9BO2S | 详情 | 详情 |
| (VIII) | 35746 | 3-[4-(methylsulfanyl)phenyl]-5-(trifluoromethyl)-2-pyridinamine; 3-[4-(methylsulfanyl)phenyl]-5-(trifluoromethyl)-2-pyridinylamine | C13H11F3N2S | 详情 | 详情 | |
| (IX) | 35747 | 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2-pyridinylamine; 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2-pyridinamine | C13H11F3N2O2S | 详情 | 详情 | |
| (X) | 35748 | 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2(1H)-pyridinone | C13H10F3NO3S | 详情 | 详情 | |
| (XI) | 35749 | 2-chloro-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine; 4-[2-chloro-5-(trifluoromethyl)-3-pyridinyl]phenyl methyl sulfone | C13H9ClF3NO2S | 详情 | 详情 |