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【结 构 式】 
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【药物名称】 【化学名称】2(S)-[3-(4-Methylsulfonylphenyl)-5-(trifluoromethyl)pyridin-2-ylsulfanyl]propan-1-ol 【CA登记号】221383-28-4 (non-specified steroch.) 【 分 子 式 】C16H16F3NO3S2 【 分 子 量 】391.43402 |
【开发单位】Merck Frosst (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Antipyretics, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-2 Inhibitors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Methyl (S)-lactate (I) was converted to chloride (II) by treatment with SOCl2. Subsequent displacement in (II) by cesium thioacetate produced thioester (III). Reduction of the ester group of (III) with concomitant thioester cleavage by means of LiAlH4 in cold THF furnished mercaptoalcohol (IV).
| 【1】 Friesen, R.W.; Deschênes, D.; Gordon, R.; Brideau, C.; Riendau, D.; Savoie, C.; Dubé, D.; Girard, Y.; Fortin, R.; Chan, C.-C.; 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 1999, 9, 12, 1715. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17075 | propionic acid, 2-hydroxy-, methyl ester, (S)-; methyl (2S)-2-hydroxypropanoate | 27871-49-4 | C4H8O3 | 详情 | 详情 |
| (II) | 35742 | methyl (2S)-2-chloropropanoate | C4H7ClO2 | 详情 | 详情 | |
| (III) | 16680 | methyl (2S)-2-(acetylsulfanyl)propanoate | C6H10O3S | 详情 | 详情 | |
| (IV) | 35743 | (2S)-2-sulfanyl-1-propanol | C3H8OS | 详情 | 详情 |
合成路线2
Bromination of 2-amino-5-trifluoromethylpyridine (V) in AcOH provided bromopyridine (VI), which was submitted to a Suzuki coupling with 4-(methylthio)benzeneboronic acid (VII) yielding the phenylpyridine derivative (VIII). Oxidation of the methylthio group of (VIII) to the corresponding sulfone (IX) was carried out by treatment with N-methylmorpholine-N-oxide in the presence of OsO4. Diazotization of the amino group of (IX) generated the pyridone (X), and further chlorination employing POCl3 provided chloropyridine (XI). Finally, condensation of (XI) with (S)-2-mercaptopropanol (IV) yielded the title compound.
| 【1】 Friesen, R.W.; Deschênes, D.; Gordon, R.; Brideau, C.; Riendau, D.; Savoie, C.; Dubé, D.; Girard, Y.; Fortin, R.; Chan, C.-C.; 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 1999, 9, 12, 1715. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 35743 | (2S)-2-sulfanyl-1-propanol | C3H8OS | 详情 | 详情 | |
| (V) | 35744 | 5-(trifluoromethyl)-2-pyridinylamine; 5-(trifluoromethyl)-2-pyridinamine | 74784-70-6 | C6H5F3N2 | 详情 | 详情 |
| (VI) | 35745 | 3-bromo-5-(trifluoromethyl)-2-pyridinamine; 3-bromo-5-(trifluoromethyl)-2-pyridinylamine | C6H4BrF3N2 | 详情 | 详情 | |
| (VII) | 18561 | 4-(methylsulfanyl)phenylboronic acid | 98546-51-1 | C7H9BO2S | 详情 | 详情 |
| (VIII) | 35746 | 3-[4-(methylsulfanyl)phenyl]-5-(trifluoromethyl)-2-pyridinamine; 3-[4-(methylsulfanyl)phenyl]-5-(trifluoromethyl)-2-pyridinylamine | C13H11F3N2S | 详情 | 详情 | |
| (IX) | 35747 | 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2-pyridinylamine; 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2-pyridinamine | C13H11F3N2O2S | 详情 | 详情 | |
| (X) | 35748 | 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-2(1H)-pyridinone | C13H10F3NO3S | 详情 | 详情 | |
| (XI) | 35749 | 2-chloro-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine; 4-[2-chloro-5-(trifluoromethyl)-3-pyridinyl]phenyl methyl sulfone | C13H9ClF3NO2S | 详情 | 详情 |